Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX, USA; Department of Medicine, Baylor College of Medicine, Houston, TX, USA; Cancer and Cellular Biology Program, Baylor College of Medicine, Houston, TX, USA.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Trends Endocrinol Metab. 2024 Sep;35(9):809-820. doi: 10.1016/j.tem.2024.04.012. Epub 2024 May 14.
Body composition impacts female fertility and there are established relationships between adipose tissue and the reproductive system. Maintaining functional adipose tissue is vital for meeting the energetic demands during the reproductive process, from ovulation to delivery and lactation. White adipose tissue (WAT) shows plastic responses to daily physiology and secretes diverse adipokines that affect the hypothalamic-pituitary-ovarian axis, but many other interorgan interactions remain to be determined. This review summarizes the current state of research on the dialogue between WAT and the female reproductive system, focusing on the impact of this crosstalk on ovarian and endometrial factors essential for fecundity.
身体成分会影响女性生育能力，脂肪组织与生殖系统之间存在着既定的关系。维持功能性脂肪组织对于满足生殖过程中的能量需求至关重要，这个过程包括排卵、分娩和哺乳。白色脂肪组织（WAT）对日常生理具有可塑性反应，并分泌多种影响下丘脑-垂体-卵巢轴的脂肪因子，但仍有许多其他器官间的相互作用有待确定。本综述总结了目前关于 WAT 与女性生殖系统之间对话的研究状况，重点讨论了这种串扰对卵巢和子宫内膜因子的影响，这些因子对生育能力至关重要。
