瘦素的生理学与病理生理学：发现30年后的已知与未知 - Suppr

Leptin physiology and pathophysiology: knowns and unknowns 30 years after its discovery.

作者信息

Flier Jeffrey S, Ahima Rexford S

机构信息

Department of Medicine and Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

出版信息

J Clin Invest. 2024 Jan 2;134(1):e174595. doi: 10.1172/JCI174595.

DOI:10.1172/JCI174595

PMID:38165042

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10760948/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c942/10760948/26d5a3b38c48/jci-134-174595-g165.jpg

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Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy.

Cell Metab. 2019 Oct 1;30(4):706-719.e6. doi: 10.1016/j.cmet.2019.08.005. Epub 2019 Sep 5.

Evidence for a Non-leptin System that Defends against Weight Gain in Overfeeding.

Cell Metab. 2018 Aug 7;28(2):289-299.e5. doi: 10.1016/j.cmet.2018.05.029. Epub 2018 Jun 21.

Toward a Wiring Diagram Understanding of Appetite Control.

Neuron. 2017 Aug 16;95(4):757-778. doi: 10.1016/j.neuron.2017.06.014.

Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy.

Expert Rev Clin Pharmacol. 2016;9(1):59-68. doi: 10.1586/17512433.2016.1096772. Epub 2015 Oct 14.

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PLoS One. 2010 Jun 29;5(6):e11376. doi: 10.1371/journal.pone.0011376.

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Cell Metab. 2006 Aug;4(2):123-32. doi: 10.1016/j.cmet.2006.06.010.

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N Engl J Med. 2004 Sep 2;351(10):987-97. doi: 10.1056/NEJMoa040388.

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Nat Med. 2004 Jul;10(7):734-8. doi: 10.1038/nm1072. Epub 2004 Jun 27.

The effects of lesions in the hypothalamus in parabiotic rats.

J Physiol. 1959 Mar 3;145(2):336-52. doi: 10.1113/jphysiol.1959.sp006145.

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Horm Metab Res. 2002 Nov-Dec;34(11-12):691-7. doi: 10.1055/s-2002-38251.

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Leptin physiology and pathophysiology: knowns and unknowns 30 years after its discovery.

作者信息

Flier Jeffrey S, Ahima Rexford S

机构信息

Department of Medicine and Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

出版信息

J Clin Invest. 2024 Jan 2;134(1):e174595. doi: 10.1172/JCI174595.

DOI:10.1172/JCI174595

PMID:38165042

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10760948/

Abstract

摘要

相似文献

Leptin physiology and pathophysiology: knowns and unknowns 30 years after its discovery.

J Clin Invest. 2024 Jan 2;134(1):e174595. doi: 10.1172/JCI174595.

Leptin and Asthma: What Are the Interactive Correlations?

Biomolecules. 2022 Nov 29;12(12):1780. doi: 10.3390/biom12121780.

Known knowns, known unknowns, unknown unknowns and unknown knowns in DNA barcoding: a comment on Dowton et al.

Syst Biol. 2014 Nov;63(6):1005-9. doi: 10.1093/sysbio/syu060. Epub 2014 Aug 12.

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Metabolism. 2024 Dec;161:156056. doi: 10.1016/j.metabol.2024.156056. Epub 2024 Oct 30.

Perioperative use of beta-adrenergic antagonists and anemia: known knowns, known unknowns, unknown unknowns; and Unknown Knowns.

Anesthesiology. 2010 Jan;112(1):12-5. doi: 10.1097/ALN.0b013e3181c5dc18.

and Plague: some knowns and unknowns.

Zoonoses. 2023;3(1). doi: 10.15212/zoonoses-2022-0040. Epub 2023 Jan 19.

The knowns and unknowns of the immunopathogenesis of tuberculosis.

Int J Tuberc Lung Dis. 2012 Nov;16(11):1424-32. doi: 10.5588/ijtld.12.0479.

Restless Legs Syndrome: Known Knowns and Known Unknowns.

Brain Sci. 2022 Jan 16;12(1):118. doi: 10.3390/brainsci12010118.

Creating an ignorance-base: Exploring known unknowns in the scientific literature.

J Biomed Inform. 2023 Jul;143:104405. doi: 10.1016/j.jbi.2023.104405. Epub 2023 Jun 1.

The known and unknown of leptin in pregnancy.

Am J Obstet Gynecol. 2006 Jun;194(6):1537-45. doi: 10.1016/j.ajog.2005.06.064. Epub 2006 Apr 21.

引用本文的文献

An alternative neural basis underlying leptin resistance.

Cell Rep. 2025 Jul 22;44(7):115863. doi: 10.1016/j.celrep.2025.115863. Epub 2025 Jun 19.

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Compr Physiol. 2025 Jun;15(3):e70018. doi: 10.1002/cph4.70018.

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Endocrinology. 2025 Jun 10;166(8). doi: 10.1210/endocr/bqaf095.

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Int J Mol Sci. 2024 Nov 26;25(23):12668. doi: 10.3390/ijms252312668.

Regulation of energy balance by leptin as an adiposity signal and modulator of the reward system.

Mol Metab. 2025 Jan;91:102078. doi: 10.1016/j.molmet.2024.102078. Epub 2024 Nov 29.

Contributions of white adipose tissue to energy requirements for female reproduction.

Trends Endocrinol Metab. 2024 Sep;35(9):809-820. doi: 10.1016/j.tem.2024.04.012. Epub 2024 May 14.

本文引用的文献

Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy.

Cell Metab. 2019 Oct 1;30(4):706-719.e6. doi: 10.1016/j.cmet.2019.08.005. Epub 2019 Sep 5.

Evidence for a Non-leptin System that Defends against Weight Gain in Overfeeding.

Cell Metab. 2018 Aug 7;28(2):289-299.e5. doi: 10.1016/j.cmet.2018.05.029. Epub 2018 Jun 21.

Toward a Wiring Diagram Understanding of Appetite Control.

Neuron. 2017 Aug 16;95(4):757-778. doi: 10.1016/j.neuron.2017.06.014.

Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy.

Expert Rev Clin Pharmacol. 2016;9(1):59-68. doi: 10.1586/17512433.2016.1096772. Epub 2015 Oct 14.

Hyperleptinemia is required for the development of leptin resistance.

PLoS One. 2010 Jun 29;5(6):e11376. doi: 10.1371/journal.pone.0011376.

Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.

Cell Metab. 2006 Aug;4(2):123-32. doi: 10.1016/j.cmet.2006.06.010.

Recombinant human leptin in women with hypothalamic amenorrhea.

N Engl J Med. 2004 Sep 2;351(10):987-97. doi: 10.1056/NEJMoa040388.

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

Nat Med. 2004 Jul;10(7):734-8. doi: 10.1038/nm1072. Epub 2004 Jun 27.

The effects of lesions in the hypothalamus in parabiotic rats.

J Physiol. 1959 Mar 3;145(2):336-52. doi: 10.1113/jphysiol.1959.sp006145.

Divergent effects of leptin in mice susceptible or resistant to obesity.

Horm Metab Res. 2002 Nov-Dec;34(11-12):691-7. doi: 10.1055/s-2002-38251.

Leptin physiology and pathophysiology: knowns and unknowns 30 years after its discovery.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

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Leptin physiology and pathophysiology: knowns and unknowns 30 years after its discovery.

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