中药健脾安胎方改善不孕女性的受精-胚胎移植妊娠结局。
Chinese medicine Jianpi Antai formula improves pregnancy outcomes of fertilization-embryo transfer in infertile women.
机构信息
Department of TCM Gynecology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, China.
Reproductive Medicine Center, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
出版信息
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2024 May 16;53(3):306-312. doi: 10.3724/zdxbyxb-2023-0536.
OBJECTIVES
To evaluate the efficacy and safety of Chinese medicine Jianpi Antai formula in infertile women undergoing fertilization-embryo transfer (IVF-ET).
METHODS
A total of 300 infertile women who underwent 2 frozen embryo transfer procedures at the Reproductive Medicine Center, Sir Run Run Shaw Hospital were included in the study. The participants were randomly divided into study group and control group. The study group received routine medication plus the Jianpi Antai formula during the period of embryo transfer, while the control group received routine medication only. The general condition, embryo implantation rate, clinical pregnancy rate, live birth rate, and the blood routine and liver and kidney function were evaluated and compared between two groups.
RESULTS
There were 277 cases who completed the study, including 134 in the study group and 143 in the control group. The embryo implantation rate (68.7% . 55.9%), the clinical pregnancy rate (56.7% . 44.8%) and the live birth rate (50.7% . 37.8%) in the study group were all higher than those in the control group (all <0.05). Subgroup analysis revealed that in patients of advanced age (≥35 years) and those with decreased ovarian reserve function (anti-Müllerian hormone <1.68 ng/mL), the embryo implantation rate, clinical pregnancy rate, and live birth rate in the study group were all higher than those in the control group (all <0.05). During the follow-up period, there were no abnormalities in the basic vital signs of both groups, and no adverse events were reported.
CONCLUSIONS
Jianpi Antai formula can safely improve the embryo implantation rate in infertile women undergoing IVF-ET, reduce the embryo miscarriage rate, increase the live birth rate as well as improve the clinical outcomes.
目的
评价健脾安胎方对行体外受精-胚胎移植（IVF-ET）的不孕患者的临床疗效及安全性。
方法
选取在浙江大学医学院附属邵逸夫医院生殖医学中心行 2 次冻融胚胎移植术的不孕患者 300 例，采用随机数字表法分为研究组和对照组，每组 150 例。研究组患者在胚胎移植期间给予常规西药联合健脾安胎方治疗，对照组患者仅给予常规西药治疗。比较两组患者的一般情况、胚胎着床率、临床妊娠率、活产率及血常规、肝肾功能等指标。
结果
最终 277 例患者完成研究，其中研究组 134 例，对照组 143 例。研究组患者的胚胎着床率（68.7%比 55.9%）、临床妊娠率（56.7%比 44.8%）和活产率（50.7%比 37.8%）均高于对照组（均 P<0.05）。亚组分析显示，在年龄≥35 岁和卵巢储备功能下降（抗苗勒管激素<1.68 ng/ml）的患者中，研究组患者的胚胎着床率、临床妊娠率和活产率均高于对照组（均 P<0.05）。随访期间两组患者基本生命体征均无异常，均未发生不良反应。
结论
健脾安胎方能安全提高行 IVF-ET 不孕患者的胚胎着床率，降低胚胎流产率，提高活产率，改善临床结局。
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