Ye Sheng-Lin, Xu Tian-Ze, Wang Chuang, Han Kang, Jiang Xu-Dong, Tang Tao, Song Bin, Du Xiao-Long, Hu Nan, Li Xiao-Qiang
Department of Vascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Front Nutr. 2024 May 1;11:1351797. doi: 10.3389/fnut.2024.1351797. eCollection 2024.
AAA is a fatal condition that commonly occurs during vascular surgery. Nutritional status exerts a significant influence on the prognosis of various pathological conditions Scores from the CONUT screening tool have been shown to predict outcomes of certain malignancies and chronic diseases. However, the ramifications of nutritional status on AAA patients undergoing EVAR have not been elucidated in prior studies. In this study, we aimed to elucidate the correlation between CONUT scores and postoperative prognostic outcomes in patients with AAA undergoing EVAR.
This was a retrospective review of 177 AAA patients treated with EVAR from June 2018 to November 2019 in a single center. Patient characteristics, CONUT scores, and postoperative status were collected. These patients were stratified into groups A and B according to CONUT scores. Subsequently, a comparative analysis of the baseline characteristics between the two cohorts was conducted. Cox proportional hazards and logistic regression analyses were employed to identify the autonomous predictors of mid-term mortality and complications, respectively.
Compared with group A, patients in group B had higher midterm mortality ( < 0.001). Univariate analysis showed that CONUT scores; respiratory diseases; stent types; preoperative Hb, CRP, PT, and Fb levels were risk factors for death. Multivariate analysis confirmed that CONUT score [HR, 1.276; 95% CI, 1.029-1.584; = 0.027] was an independent risk factor for mortality. Logistic regression analysis showed that prior arterial disease, smoking, and D-dimer levels were risk factors, although multivariate analysis showed smoking (OR, 3.492; 95% CI, 1.426-8.553; = 0.006) was an independent risk factor. Kaplan-Meier curves showed that patients in group B had shorter mid-term survival than those in group A (log-rank < 0.001).
Malnutrition was strongly associated with mid-term mortality in patients with infrarenal AAA treated with EVAR.
腹主动脉瘤(AAA)是一种常见于血管手术期间的致命疾病。营养状况对各种病理状况的预后有重大影响。CONUT筛查工具的评分已被证明可预测某些恶性肿瘤和慢性疾病的预后。然而,先前的研究尚未阐明营养状况对接受腔内血管修复术(EVAR)的AAA患者的影响。在本研究中,我们旨在阐明接受EVAR的AAA患者的CONUT评分与术后预后结果之间的相关性。
这是一项对2018年6月至2019年11月在单一中心接受EVAR治疗的177例AAA患者的回顾性研究。收集患者的特征、CONUT评分和术后状况。根据CONUT评分将这些患者分为A组和B组。随后,对两组队列的基线特征进行比较分析。采用Cox比例风险模型和逻辑回归分析分别确定中期死亡率和并发症的自主预测因素。
与A组相比,B组患者的中期死亡率更高(<0.001)。单因素分析显示,CONUT评分、呼吸系统疾病、支架类型、术前血红蛋白(Hb)、C反应蛋白(CRP)、凝血酶原时间(PT)和纤维蛋白原(Fb)水平是死亡的危险因素。多因素分析证实,CONUT评分[风险比(HR),1.276;95%置信区间(CI),1.029 - 1.584;P = 0.027]是死亡率的独立危险因素。逻辑回归分析显示,既往动脉疾病、吸烟和D - 二聚体水平是危险因素,尽管多因素分析显示吸烟(比值比(OR),3.492;95% CI,1.426 - 8.553;P = 0.006)是独立危险因素。Kaplan - Meier曲线显示,B组患者的中期生存期短于A组患者(对数秩检验<0.001)。
营养不良与接受EVAR治疗的肾下型AAA患者的中期死亡率密切相关。