Selvaraj Karthikeyan, Shankar Aiswerya, Johnson Thanka, M Preethi
General Surgery, Sree Balaji Medical College and Hospital, Chennai, IND.
Pathology, Sree Balaji Medical College and Hospital, Chennai, IND.
Cureus. 2024 Apr 15;16(4):e58291. doi: 10.7759/cureus.58291. eCollection 2024 Apr.
The incidence of mixed thyroid carcinoma of poorly differentiated thyroid carcinoma (PDTC) and papillary carcinoma thyroid is very unusual. PDTC exhibits a high degree of dedifferentiation and histopathological confirmation is done based on Turin's criteria. This type of carcinoma has a poor prognosis and the survival rates at five and ten years post-diagnosis are significantly lower compared to well-differentiated thyroid carcinomas. Surgery is the best mode of treatment at present. This is a case of a 71-year-old female who underwent total thyroidectomy with modified radical neck dissection which yielded a histopathological variant comprising PDTC and papillary thyroid carcinoma. The patient was followed up with a serial thyroglobulin antibody test and ultrasound of the neck at six months and one year, and both were found to be normal.
低分化甲状腺癌(PDTC)与甲状腺乳头状癌混合性甲状腺癌的发病率非常罕见。PDTC表现出高度的去分化,组织病理学诊断依据都灵标准进行。这种类型的癌预后较差,与高分化甲状腺癌相比,诊断后5年和10年的生存率显著降低。目前手术是最佳治疗方式。这是一例71岁女性患者,接受了全甲状腺切除术及改良根治性颈清扫术,术后病理结果为PDTC与甲状腺乳头状癌的组织病理学变异型。对该患者在术后6个月和1年进行了系列甲状腺球蛋白抗体检测及颈部超声检查进行随访,结果均正常。