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一种罕见的混合性甲状腺癌：手术及病理学上的罕见病例。

An Unusual Mixed Thyroid Carcinoma: A Surgical and Pathological Rarity.

作者信息

Selvaraj Karthikeyan, Shankar Aiswerya, Johnson Thanka, M Preethi

机构信息

General Surgery, Sree Balaji Medical College and Hospital, Chennai, IND.

Pathology, Sree Balaji Medical College and Hospital, Chennai, IND.

出版信息

Cureus. 2024 Apr 15;16(4):e58291. doi: 10.7759/cureus.58291. eCollection 2024 Apr.

DOI:10.7759/cureus.58291
PMID:38752032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11094661/
Abstract

The incidence of mixed thyroid carcinoma of poorly differentiated thyroid carcinoma (PDTC) and papillary carcinoma thyroid is very unusual. PDTC exhibits a high degree of dedifferentiation and histopathological confirmation is done based on Turin's criteria. This type of carcinoma has a poor prognosis and the survival rates at five and ten years post-diagnosis are significantly lower compared to well-differentiated thyroid carcinomas. Surgery is the best mode of treatment at present. This is a case of a 71-year-old female who underwent total thyroidectomy with modified radical neck dissection which yielded a histopathological variant comprising PDTC and papillary thyroid carcinoma. The patient was followed up with a serial thyroglobulin antibody test and ultrasound of the neck at six months and one year, and both were found to be normal.

摘要

低分化甲状腺癌（PDTC）与甲状腺乳头状癌混合性甲状腺癌的发病率非常罕见。PDTC表现出高度的去分化，组织病理学诊断依据都灵标准进行。这种类型的癌预后较差，与高分化甲状腺癌相比，诊断后5年和10年的生存率显著降低。目前手术是最佳治疗方式。这是一例71岁女性患者，接受了全甲状腺切除术及改良根治性颈清扫术，术后病理结果为PDTC与甲状腺乳头状癌的组织病理学变异型。对该患者在术后6个月和1年进行了系列甲状腺球蛋白抗体检测及颈部超声检查进行随访，结果均正常。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/f8375ad57db2/cureus-0016-00000058291-i12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/617a4d4bf86e/cureus-0016-00000058291-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/d350a0e0c045/cureus-0016-00000058291-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/230af31cb356/cureus-0016-00000058291-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/5aa657177e56/cureus-0016-00000058291-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/76057c35a0e7/cureus-0016-00000058291-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/06c26768131e/cureus-0016-00000058291-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/fc0fb9f6fe68/cureus-0016-00000058291-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/c49ad65f8f17/cureus-0016-00000058291-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/510ba3079b9a/cureus-0016-00000058291-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/0fb5aa18709f/cureus-0016-00000058291-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/ada8e6bfb9cb/cureus-0016-00000058291-i11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/f8375ad57db2/cureus-0016-00000058291-i12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/617a4d4bf86e/cureus-0016-00000058291-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/d350a0e0c045/cureus-0016-00000058291-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/230af31cb356/cureus-0016-00000058291-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/5aa657177e56/cureus-0016-00000058291-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/76057c35a0e7/cureus-0016-00000058291-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/06c26768131e/cureus-0016-00000058291-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/fc0fb9f6fe68/cureus-0016-00000058291-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/c49ad65f8f17/cureus-0016-00000058291-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/510ba3079b9a/cureus-0016-00000058291-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/0fb5aa18709f/cureus-0016-00000058291-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/ada8e6bfb9cb/cureus-0016-00000058291-i11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1122/11094661/f8375ad57db2/cureus-0016-00000058291-i12.jpg

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本文引用的文献

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The impact of thyroid tumor features on lymph node metastasis in papillary thyroid carcinoma patients in head and neck department at KAMC: A retrospective cross-sectional study.喀土穆军事学院头颈科甲状腺乳头状癌患者甲状腺肿瘤特征对淋巴结转移的影响：一项回顾性横断面研究。
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