Beg Mohammed Suleman, Gibbons Ella Nicole, Gavalas Spyridon, Holden Mark A, Krysmann Marta, Kelarakis Antonios
UCLan Research Centre for Smart Materials, School of Pharmacy and Biomedical Sciences, University of Central Lancashire Preston PR1 2HE UK
School of Medicine and Dentistry, University of Central Lancashire Preston PR1 2HE UK.
Nanoscale Adv. 2024 Mar 15;6(10):2594-2601. doi: 10.1039/d3na01154b. eCollection 2024 May 14.
We present a novel type of layer-by-layer (LbL) waterborne coating based on Nafion and amine-terminated graphene oxide (GO-NH) that inhibits the growth of and by more than 99% and this performance is not compromised upon extensive thermal annealing at 200 °C. Quartz crystal microbalance (QCM) sensorgrams allow the real time monitoring of the build-up of the LbL assemblies, a process that relies on the strong electrostatic interactions between Nafion (pH = 2.7, = -54.8 mV) and GO-NH (pH = 2, = 26.7 mV). Atomic force microscopy (AFM), contact angle and zeta potential measurements were used to characterise the multilayer assemblies. We demonstrate here that Nafion/GO-NH advanced coatings can offer drug-free and long-lasting solutions to microbial colonization and can withstand dry heat sterilization, without any decline in their performance.
我们展示了一种基于全氟磺酸离子交换膜（Nafion）和胺基化氧化石墨烯（GO-NH）的新型逐层（LbL）水性涂层，该涂层能抑制[具体微生物名称1]和[具体微生物名称2]的生长，抑制率超过99%，并且在200°C下进行长时间热退火后，这种性能不会受到影响。石英晶体微天平（QCM）传感器图谱能够实时监测LbL组装体的形成过程，该过程依赖于Nafion（pH = 2.7，ζ = -54.8 mV）与GO-NH（pH = 2，ζ = 26.7 mV）之间强烈的静电相互作用。利用原子力显微镜（AFM）、接触角和zeta电位测量对多层组装体进行了表征。我们在此证明，Nafion/GO-NH先进涂层可为微生物定植提供无药物且持久的解决方案，并且能够承受干热灭菌，而其性能不会有任何下降。
