Medical College of Wisconsin, Department of Pediatrics, Division of Nephrology, Milwaukee, Wisconsin.
Cincinnati Children's Hospital Medical Center, University of Cincinnati, Department of Pediatrics, Division of Rheumatology, Ohio, USA.
Curr Opin Rheumatol. 2024 Sep 1;36(5):322-327. doi: 10.1097/BOR.0000000000001027. Epub 2024 May 16.
This review will provide updates in the outcomes in the common rheumatologic diseases with kidney involvement. Covered are also advances in therapeutics for the use of pediatric rheumatologic diseases with kidney involvement, as well as the potential kidney complications from other rheumatologic diseases and their medications.
Two of the more common rheumatologic diseases with kidney involvement, lupus and vasculitis, continue to show inadequate response to initial therapy of renal disease and practice continues to be driven by results of adult studies.
There is a continued need for pediatric specific studies in rheumatologic diseases with kidney involvement as outcomes continue to be inadequate. Despite recently approved treatments for adults with rheumatic diseases and kidney involvement, therapeutic options in pediatrics remain limited, contributing to the overall morbidity and mortality.
本文将对伴有肾脏受累的常见风湿性疾病的结局进行更新。同时还涵盖了治疗儿科风湿性疾病伴有肾脏受累的进展，以及其他风湿性疾病及其药物治疗的潜在肾脏并发症。
两种更常见的伴有肾脏受累的风湿性疾病，狼疮和血管炎，对肾脏疾病的初始治疗反应仍然不充分，并且实践继续受到成人研究结果的驱动。
伴有肾脏受累的风湿性疾病仍需要进行儿科特定的研究，因为其结局仍不充分。尽管最近批准了成人风湿性疾病和肾脏受累的治疗方法，但儿科的治疗选择仍然有限，这导致了整体发病率和死亡率的增加。
