Division of Nephrology and Hypertension, Department of Pediatrics, Children's Hospital of Michigan, 3901 Beaubien Boulevard, MI, 48201, USA; Department of Pediatrics, Central Michigan University College of Medicine, 1280 East Campus Drive, Mount Pleasant, MI 48858, USA.
Department of Pediatrics, Wayne State University School of Medicine, 540 East Canfield Street, Detroit, MI 48201, USA.
Pediatr Clin North Am. 2022 Dec;69(6):1199-1217. doi: 10.1016/j.pcl.2022.07.009. Epub 2022 Oct 29.
Pediatric vasculitis is a complex group of disorders that commonly presents with multisystem involvement. Renal vasculitis can be isolated to the kidneys or can occur as part of a broader multiorgan vasculitis. Depending on severity, renal vasculitis may present as acute glomerulonephritis (AGN) often associated with hypertension and sometimes with a rapidly deteriorating clinical course. Prompt diagnosis and initiation of therapy are key to preserving kidney function and preventing long-term morbidity and mortality. This review focuses on the clinical presentation, diagnosis, and treatment objectives for common forms of renal vasculitis seen in pediatric patients.
儿科血管炎是一组常见多系统受累的复杂疾病。肾血管炎可单独累及肾脏，也可作为更广泛多器官血管炎的一部分。根据严重程度，肾血管炎可表现为急性肾小球肾炎（AGN），常伴有高血压，有时伴有临床病情迅速恶化。及时诊断和开始治疗是保护肾功能和预防长期发病率和死亡率的关键。本文重点介绍儿科患者常见肾血管炎的临床表现、诊断和治疗目标。
