Perussia B, London L, Trinchieri G
Biomed Pharmacother. 1985;39(1):13-8.
Surface antigen analysis of human natural killer (NK) cells using anti-lymphocyte monoclonal antibodies identifies NK cells as a discrete cell type (average 15% of peripheral blood lymphocytes) distinct from T, B, and myelomonocytic cells. Virtually all NK cells bear low-affinity Fc receptors for IgG, as detected by antibody B73.1 and N901 antigen; 80-90% of NK cells express the E receptor (OKT11), the C3bi receptor (OKM1), and the T10 antigen; 30-50% are T8 (+), and 30-70% are Leu7 (+). This phenotype is maintained on NK cell-derived clones and on activated NK cells, which are induced to express interleukin 2 receptor (Tac antigen), transferrin receptor, HLA-DR, and several T cell activation antigens but not, like resting NK cells, antigens (T1, T3, T4) characteristic of T cells. On the contrary, NK cell-derived leukemias may express T1 or, more frequently, T3 antigens.
使用抗淋巴细胞单克隆抗体对人类自然杀伤（NK）细胞进行表面抗原分析，可将NK细胞识别为一种与T细胞、B细胞和骨髓单核细胞不同的离散细胞类型（平均占外周血淋巴细胞的15%）。实际上，如通过抗体B73.1和N901抗原检测到的，所有NK细胞都带有低亲和力的IgG Fc受体；80-90%的NK细胞表达E受体（OKT11）、C3bi受体（OKM1）和T10抗原；30-50%为T8（+），30-70%为Leu7（+）。这种表型在NK细胞衍生的克隆以及活化的NK细胞上得以维持，活化的NK细胞被诱导表达白细胞介素2受体（Tac抗原）、转铁蛋白受体、HLA-DR以及几种T细胞活化抗原，但与静息NK细胞不同的是，它们不表达T细胞特有的抗原（T1、T3、T4）。相反，NK细胞衍生的白血病可能表达T1抗原，或者更常见的是T3抗原。
