Aurias A, Dumont J, Mazabraud A, Lenoir G
Cancer Genet Cytogenet. 1985 Sep;18(1):55-63. doi: 10.1016/0165-4608(85)90040-8.
A non-Hodgkin's lymphoma was observed in a patient who had been treated for Hodgkin's disease (HD). The initial treatment consisted of radiotherapy alone, but following three subsequent relapses, both chemotherapy and radiotherapy were administered several times. Twenty years later, the biopsy of an isolated cervical lymph node revealed a non-Hodgkin's lymphoma. The histologic subtype was immunoblastic. Cytogenetic studies of the tumoral cells revealed a t(8;14)(q24;q32) translocation. At the same time, multiple chromosomal rearrangements were observed in peripheral blood lymphocytes, especially t(7;14)(q35;q12), which was noted in 6 of 53 mitoses. This anomaly, frequently observed in patients with ataxia telangiectasia or severe immunodeficiency, has not previously been described in such circumstances.
在一名曾接受霍奇金病（HD）治疗的患者中观察到非霍奇金淋巴瘤。初始治疗仅包括放疗，但在随后三次复发后，化疗和放疗均多次进行。二十年后，对一个孤立的颈部淋巴结进行活检显示为非霍奇金淋巴瘤。组织学亚型为免疫母细胞型。肿瘤细胞的细胞遗传学研究显示存在t(8;14)(q24;q32)易位。同时，在外周血淋巴细胞中观察到多个染色体重排，尤其是t(7;14)(q35;q12)，在53个有丝分裂中6个观察到该异常。这种异常在共济失调毛细血管扩张症或严重免疫缺陷患者中经常观察到，但此前在这种情况下尚未有描述。
