Wlodarska I, Delabie J, De Wolf-Peeters C, Mecucci C, Stul M, Verhoef G, Cassiman J J, Van den Berghe H
Centre for Human Genetics, University of Leuven, Belgium.
J Pathol. 1993 Jul;170(3):239-48. doi: 10.1002/path.1711700305.
A case of peripheral T-cell lymphoma (PTL) occurring in a patient with Hodgkin's disease (HD) in relapse is described. The second neoplasm developed 25 months after the diagnosis of HD. Cytogenetic analysis on the lymph node biopsy at the time of diagnosis of PTL revealed the co-existence of two distinct, abnormal cell clones. The first clone was characterized by a reciprocal translocation t(5;7)(q13;q35) involving 7q35, namely the TCR-beta gene, as expected in T-cell lymphomas. The second cell clone carried trisomies for chromosomes 2, 5, 7, and 14. By immunophenotypic and molecular analysis as well as by in situ hybridization, it was possible to prove that the malignant T-cells and the Reed-Sternberg cells corresponded to different cell clones, one carrying the structural chromosome abnormalities and one carrying the numerical chromosome anomalies. These results indicate that the present case represented a true composite lymphoma.
本文描述了1例霍奇金淋巴瘤（HD）复发患者发生外周T细胞淋巴瘤（PTL）的病例。第二种肿瘤在HD诊断后25个月出现。PTL诊断时对淋巴结活检进行的细胞遗传学分析显示存在两个不同的异常细胞克隆。第一个克隆的特征是涉及7q35的相互易位t(5;7)(q13;q35)，7q35即TCR-β基因，这在T细胞淋巴瘤中是预期的。第二个细胞克隆携带2号、5号、7号和14号染色体三体。通过免疫表型和分子分析以及原位杂交，有可能证明恶性T细胞和里德-斯腾伯格细胞对应于不同的细胞克隆，一个携带结构性染色体异常，另一个携带数量性染色体异常。这些结果表明本病例代表一种真正的复合淋巴瘤。
