α-葡萄糖苷水解酶抑制作用及人体对蔗糖、水和钠的肠道吸收效应
Effect of alpha-glucosidehydrolase inhibition and intestinal absorption of sucrose, water, and sodium in man.
作者信息
Caspary W F, Kalisch H
出版信息
Gut. 1979 Sep;20(9):750-5. doi: 10.1136/gut.20.9.750.
The effect of a new complex oligosaccharide exhibiting potent inhibitory action on alpha-glucoside hydrolases on intestinal absorption of sucrose in man was tested by constant in vivo perfusion of the jejunum. At concentrations of 4.65 or 15.5 X 10(-6)M the alpha-glucosidehydrolase inhibitor (alpha-GHI) markedly inhibited absorption of glucose from sucrose and absorption of sodium and water. Oral administration of the alpha-GHI resulted as well in depression of solute, sodium, and water absorption. This new compound can serve as an interesting tool to induce carbohydrate malabsorption by inhibition of final digestion and may possibly be of beneficial therapeutic effect in dietary control of diabetes or obesity.
通过对空肠进行持续的体内灌注，测试了一种对α-葡萄糖苷酶具有强效抑制作用的新型复合寡糖对人体蔗糖肠道吸收的影响。在浓度为4.65或15.5×10⁻⁶M时，α-葡萄糖苷酶抑制剂（α-GHI）显著抑制了蔗糖中葡萄糖的吸收以及钠和水的吸收。口服α-GHI也导致溶质、钠和水吸收的减少。这种新化合物可作为一种有趣的工具，通过抑制最终消化来诱导碳水化合物吸收不良，并且可能在糖尿病或肥胖症的饮食控制中具有有益的治疗效果。
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