接受α-葡萄糖苷酶抑制剂治疗的胰岛素治疗糖尿病患者的代谢状况得到改善。
Improved metabolic profiles in insulin-treated diabetic patients given an alpha-glucosidehydrolase inhibitor.
作者信息
Walton R J, Sherif I T, Noy G A, Alberti K G
出版信息
Br Med J. 1979 Jan 27;1(6158):220-1. doi: 10.1136/bmj.1.6158.220.
Abstract
An alpha-glucosidehydrolase inhibitor (acarbose; BAY g 5421) taken with food was compared with dummy tablets in seven insulin-treated diabetic patients over eight-hour periods that included breakfast, lunch, and two snacks. Acarbose diminished the postprandial increases in blood glucose, lactate, and pyruvate concentrations and may therefore be of value in the management of insulin-dependent diabetes.
摘要
在7名接受胰岛素治疗的糖尿病患者中，将随餐服用的α-葡萄糖苷水解酶抑制剂（阿卡波糖；BAY g 5421）与安慰剂片在包括早餐、午餐和两次小吃的8小时时间段内进行了比较。阿卡波糖可减轻餐后血糖、乳酸和丙酮酸浓度的升高，因此可能对胰岛素依赖型糖尿病的治疗有价值。
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