接受α-葡萄糖苷酶抑制剂治疗的胰岛素治疗糖尿病患者的代谢状况得到改善。
Improved metabolic profiles in insulin-treated diabetic patients given an alpha-glucosidehydrolase inhibitor.
作者信息
Walton R J, Sherif I T, Noy G A, Alberti K G
出版信息
Br Med J. 1979 Jan 27;1(6158):220-1. doi: 10.1136/bmj.1.6158.220.
Abstract
An alpha-glucosidehydrolase inhibitor (acarbose; BAY g 5421) taken with food was compared with dummy tablets in seven insulin-treated diabetic patients over eight-hour periods that included breakfast, lunch, and two snacks. Acarbose diminished the postprandial increases in blood glucose, lactate, and pyruvate concentrations and may therefore be of value in the management of insulin-dependent diabetes.
摘要
在7名接受胰岛素治疗的糖尿病患者中，将随餐服用的α-葡萄糖苷水解酶抑制剂（阿卡波糖；BAY g 5421）与安慰剂片在包括早餐、午餐和两次小吃的8小时时间段内进行了比较。阿卡波糖可减轻餐后血糖、乳酸和丙酮酸浓度的升高，因此可能对胰岛素依赖型糖尿病的治疗有价值。
相似文献
1
Improved metabolic profiles in insulin-treated diabetic patients given an alpha-glucosidehydrolase inhibitor.接受α-葡萄糖苷酶抑制剂治疗的胰岛素治疗糖尿病患者的代谢状况得到改善。
Br Med J. 1979 Jan 27;1(6158):220-1. doi: 10.1136/bmj.1.6158.220.
2
Effect of the alpha-glucosidase-inhibitor BAY-g-5421 on blood glucose control of sulphonylurea-treated diabetics and insulin-treated diabetics.
Diabetologia. 1979 Nov;17(5):287-90. doi: 10.1007/BF01235884.
3
Improvement of metabolic control in insulin dependent diabetics treated with the alpha-glucosidase inhibitor acarbose for two months.使用α-葡萄糖苷酶抑制剂阿卡波糖治疗两个月的胰岛素依赖型糖尿病患者代谢控制的改善情况。
Diabetologia. 1981 Nov;21(5):446-51. doi: 10.1007/BF00257784.
4
alpha-Glucosidase inhibition improves postprandial hyperglycemia and decreases insulin requirements in insulin-dependent diabetes mellitus.
Metabolism. 1985 Mar;34(3):261-5. doi: 10.1016/0026-0495(85)90010-1.
5
Effect of alpha-glucosidehydrolase inhibition and intestinal absorption of sucrose, water, and sodium in man.α-葡萄糖苷水解酶抑制作用及人体对蔗糖、水和钠的肠道吸收效应
Gut. 1979 Sep;20(9):750-5. doi: 10.1136/gut.20.9.750.
6
The effects of the alpha-glucosidase inhibitor BAY g 5421 (Acarbose) on postprandial blood glucose, serum insulin, and triglyceride levels: dose-time-response relationships in man.
Res Exp Med (Berl). 1979 Apr 23;175(1):87-94. doi: 10.1007/BF01851237.
7
The effects of the alpha-glucosidase inhibitor BAY g 5421 (Acarbose) on meal-stimulated elevations of circulating glucose, insulin, and triglyceride levels in man.
Res Exp Med (Berl). 1979 Apr 23;175(1):81-6. doi: 10.1007/BF01851236.
8
Effects of prolonged (6 months) alpha-glucosidase inhibition on blood glucose control and insulin requirements in patients with insulin-dependent diabetes mellitus.长期（6个月）α-葡萄糖苷酶抑制对胰岛素依赖型糖尿病患者血糖控制及胰岛素需求的影响。
Horm Metab Res. 1986 Apr;18(4):253-5. doi: 10.1055/s-2007-1012287.
9
The effect of alpha-glucosidase inhibition on intestinal disaccharidase activity in normal and diabetic mice.α-葡萄糖苷酶抑制对正常及糖尿病小鼠肠道双糖酶活性的影响。
Metabolism. 1983 Aug;32(8):793-9. doi: 10.1016/0026-0495(83)90109-9.
10
A glycoside-hydrolase inhibitor in treatment of dumping syndrome.
Lancet. 1979 Sep 22;2(8143):603-5. doi: 10.1016/s0140-6736(79)91665-9.
引用本文的文献
1
The α-Glucosidase Inhibition Activities of Phaeochromycins D and E Isolated from Marine sp. FJ0218.从海洋菌株FJ0218中分离得到的嗜铬霉素D和E的α-葡萄糖苷酶抑制活性
Molecules. 2025 Apr 30;30(9):1993. doi: 10.3390/molecules30091993.
2
Acarbose glycosylation by AcbE for the production of acarstatins with enhanced α-amylase inhibitory activity.通过AcbE对阿卡波糖进行糖基化修饰以生产具有增强α-淀粉酶抑制活性的阿卡他汀。
Synth Syst Biotechnol. 2024 Mar 15;9(2):359-368. doi: 10.1016/j.synbio.2024.03.006. eCollection 2024 Jun.
3
Glucose Deprivation Induced by Acarbose and Oncolytic Newcastle Disease Virus Promote Metabolic Oxidative Stress and Cell Death in a Breast Cancer Model.阿卡波糖和溶瘤新城疫病毒诱导的葡萄糖剥夺在乳腺癌模型中促进代谢性氧化应激和细胞死亡。
Front Mol Biosci. 2022 Jul 22;9:816510. doi: 10.3389/fmolb.2022.816510. eCollection 2022.
4
Potential risk of alpha-glucosidase inhibitor administration in prostate cancer external radiotherapy by exceptional rectal gas production: a case report.α-葡萄糖苷酶抑制剂在前列腺癌体外放疗中因异常直肠产气导致的潜在风险：一例报告
J Med Case Rep. 2014 May 5;8:136. doi: 10.1186/1752-1947-8-136.
5
Oral antidiabetic drug use in the elderly.老年人使用口服抗糖尿病药物。
Drugs Aging. 1996 Dec;9(6):418-37. doi: 10.2165/00002512-199609060-00005.
6
Evaluation of differential disaccharide excretion in urine for non-invasive investigation of altered intestinal disaccharidase activity caused by alpha-glucosidase inhibition, primary hypolactasia, and coeliac disease.评估尿中双糖排泄差异用于对由α-葡萄糖苷酶抑制、原发性乳糖酶缺乏症和乳糜泻引起的肠道双糖酶活性改变进行无创性研究。
Gut. 1996 Sep;39(3):374-81. doi: 10.1136/gut.39.3.374.
7
Long-term treatment of sulphonylurea-treated diabetics with the alpha-glucosidase inhibitor Bay g 5421 (acarbose).用α-葡萄糖苷酶抑制剂拜糖平（阿卡波糖）对磺脲类治疗的糖尿病患者进行长期治疗。
Diabetologia. 1981 May;20(5):586. doi: 10.1007/BF00252772.
8
Effect of a long-term acarbose therapy on the metabolic control of sulphonylurea-treated diabetic patients.长期服用阿卡波糖对磺脲类药物治疗的糖尿病患者代谢控制的影响。
Diabetologia. 1982 Mar;22(3):221. doi: 10.1007/BF00283759.
9
Improvement of metabolic control in insulin dependent diabetics treated with the alpha-glucosidase inhibitor acarbose for two months.使用α-葡萄糖苷酶抑制剂阿卡波糖治疗两个月的胰岛素依赖型糖尿病患者代谢控制的改善情况。
Diabetologia. 1981 Nov;21(5):446-51. doi: 10.1007/BF00257784.
10
Glycogen storage disease type I. Results of treatment with frequent daytime feeding, combined with nocturnal intragastric feeding and with administration of an alpha-glucosidase inhibitor.
Eur J Pediatr. 1983 Apr;140(2):102-4. doi: 10.1007/BF00441652.
本文引用的文献
1
Effect of multiple daily insulin injections on the course of diabetic retinopathy.每日多次胰岛素注射对糖尿病视网膜病变病程的影响。
Diabetes. 1976 May;25(5):463-9.
2
[Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973 (author's transl)].
Diabete Metab. 1977 Jun;3(2):97-107.
3
Dietary fibres, fibre analogues, and glucose tolerance: importance of viscosity.膳食纤维、纤维类似物与葡萄糖耐量：黏度的重要性。
Br Med J. 1978 May 27;1(6124):1392-4. doi: 10.1136/bmj.1.6124.1392.
4
alpha-Glucosidase inhibitors. New complex oligosaccharides of microbial origin.
Naturwissenschaften. 1977 Oct;64(10):535-6. doi: 10.1007/BF00483561.
5
Sucrose malabsorption in man after ingestion of alpha-glucosidehydrolase inhibitor.
Lancet. 1978 Jun 10;1(8076):1231-3. doi: 10.1016/s0140-6736(78)92466-2.
6
Unabsorbable carbohydrates and diabetes: Decreased post-prandial hyperglycaemia.不可吸收碳水化合物与糖尿病：餐后高血糖降低。
Lancet. 1976 Jul 24;2(7978):172-4. doi: 10.1016/s0140-6736(76)92346-1.
Zotero 插件