Department of Trace Analysis, Faculty of Chemistry, Adam Mickiewicz University in Poznań, 8 Uniwersytetu Poznańskiego Street, 61-614, Poznań, Poland.
Department of Trace Analysis, Faculty of Chemistry, Adam Mickiewicz University in Poznań, 8 Uniwersytetu Poznańskiego Street, 61-614, Poznań, Poland.
Talanta. 2024 Aug 15;276:126240. doi: 10.1016/j.talanta.2024.126240. Epub 2024 May 10.
Arsenic has been an element of great interest among scientists for many years as it is a widespread metalloid in our ecosystem. Arsenic is mostly recognized with negative connotations due to its toxicity. Surely, most of us know that a long time ago, arsenic trioxide was used in medicine to treat, mainly, skin diseases. However, not everyone knows about its very wide and promising use in the treatment of cancer. Initially, in the seventies, it was used to treat leukemia, but new technological possibilities and the development of nanotechnology have made it possible to use arsenic trioxide for the treatment of solid tumours. The most toxic arsenic compound - arsenic trioxide - as the basis of anticancer drugs in which they function as a component of nanoparticles is used in the fight against various types of cancer. This review aims to present the current solutions in various cancer treatment using arsenic compounds with different binding motifs and methods of preparation to create targeted nanoparticles, nanodiamonds, nanohybrids, nanodrugs, or nanovehicles.
砷多年来一直是科学家们非常感兴趣的元素，因为它是我们生态系统中广泛存在的类金属。由于其毒性，砷大多带有负面含义。当然，我们大多数人都知道，很久以前，三氧化二砷曾被用于医学治疗，主要是皮肤病。然而，并非每个人都知道它在癌症治疗方面非常广泛和有前途的用途。最初，在 70 年代，它被用于治疗白血病，但新的技术可能性和纳米技术的发展使得三氧化二砷有可能用于治疗实体瘤。最毒的砷化合物——三氧化二砷——作为抗癌药物的基础，其中它们作为纳米颗粒的一个组成部分发挥作用，用于对抗各种类型的癌症。本综述旨在介绍使用具有不同结合基序和制备方法的砷化合物在各种癌症治疗中的最新解决方案，以创建靶向纳米颗粒、纳米金刚石、纳米杂化、纳米药物或纳米载体。
