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砷中毒性多发性神经病酷似吉兰-巴雷综合征：一个难题。

Arsenic-Induced Polyneuropathy Mimicking Guillain-Barré Syndrome: A Conundrum.

作者信息

Behrens-van Tonder Carin, Smit Liesl

机构信息

Neurology University of the Free State Faculty of Health Sciences Bloemfontein South Africa.

出版信息

Clin Case Rep. 2025 Sep 8;13(9):e70853. doi: 10.1002/ccr3.70853. eCollection 2025 Sep.

DOI:10.1002/ccr3.70853
PMID:40933293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12417313/
Abstract

We present a patient with flaccid paralysis caused by chronic arsenic exposure, most likely due to illicit drug use. Arsenic is known to cause polyneuropathy, but is not often considered in the differential diagnosis of a patient presenting with flaccid paralysis.

摘要

我们报告一名因长期接触砷导致弛缓性麻痹的患者，很可能是由于使用非法药物所致。已知砷会引起多发性神经病，但在以弛缓性麻痹就诊患者的鉴别诊断中并不常被考虑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b1/12417313/56bb2d1c3d2d/CCR3-13-e70853-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b1/12417313/8deafd110c09/CCR3-13-e70853-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b1/12417313/bfd8c48cabac/CCR3-13-e70853-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b1/12417313/391c4f8ab5ce/CCR3-13-e70853-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b1/12417313/72ec726458c1/CCR3-13-e70853-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b1/12417313/56bb2d1c3d2d/CCR3-13-e70853-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b1/12417313/8deafd110c09/CCR3-13-e70853-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b1/12417313/bfd8c48cabac/CCR3-13-e70853-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b1/12417313/391c4f8ab5ce/CCR3-13-e70853-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b1/12417313/72ec726458c1/CCR3-13-e70853-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8b1/12417313/56bb2d1c3d2d/CCR3-13-e70853-g001.jpg

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本文引用的文献

1
Can arsenic do anything good? Arsenic nanodrugs in the fight against cancer - last decade review.砷能有什么好处呢？砷纳米药物在抗癌中的应用——过去十年的回顾。
Talanta. 2024 Aug 15;276:126240. doi: 10.1016/j.talanta.2024.126240. Epub 2024 May 10.
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Arsenic trioxide: applications, mechanisms of action, toxicity and rescue strategies to date.三氧化二砷：应用、作用机制、毒性及迄今的抢救策略。
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Mechanisms Associated with Cognitive and Behavioral Impairment Induced by Arsenic Exposure.
砷暴露致认知和行为损伤的相关机制。
Cells. 2023 Oct 28;12(21):2537. doi: 10.3390/cells12212537.
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Molecular Mechanism of Arsenic-Induced Neurotoxicity including Neuronal Dysfunctions.砷诱导的神经毒性的分子机制，包括神经元功能障碍。
Int J Mol Sci. 2021 Sep 17;22(18):10077. doi: 10.3390/ijms221810077.
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Toxicity in Peripheral Nerves: An Overview.周围神经毒性：概述
Toxics. 2021 Sep 11;9(9):218. doi: 10.3390/toxics9090218.
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The impact of chronic co-exposure to different heavy metals on small fibers of peripheral nerves. A study of metal industry workers.长期同时接触不同重金属对周围神经小纤维的影响。一项针对金属行业工人的研究。
J Occup Med Toxicol. 2021 Apr 15;16(1):12. doi: 10.1186/s12995-021-00302-6.
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Arsenic exposure with reference to neurological impairment: an overview.砷暴露与神经损伤：概述。
Rev Environ Health. 2019 Dec 18;34(4):403-414. doi: 10.1515/reveh-2019-0052.
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Subacute Arsenic Neuropathy: Clinical and Electrophysiological Observations.亚急性砷中毒性神经病：临床与电生理观察
J Neurosci Rural Pract. 2019 Jul;10(3):529-532. doi: 10.1055/s-0039-1695693. Epub 2019 Oct 9.
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Arsenic Neurotoxicity in Humans.砷的神经毒性作用
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Total arsenic and speciation analysis of saliva and urine samples from individuals living in a chronic arsenicosis area in China.中国慢性砷中毒地区人群唾液和尿液中总砷及砷形态分析。
Environ Health Prev Med. 2017 May 11;22(1):45. doi: 10.1186/s12199-017-0652-5.