Kajawara T, Szuki T, Tobe T
Gut. 1979 Sep;20(9):806-10. doi: 10.1136/gut.20.9.806.
Pancreatic endocrine function was studied in 13 patients who had undergone massive bowel resection. The patients were divided into two groups: one month after operation (short-term group), and three or more months after operation (long-term group). Oral administration of glucose caused a persistent low insulin secretion in almost all the patients and the glucose tolerance curve showed a diabetic pattern in four. In contrast, the insulin response to intravenously infused arginine was impaired in the short-term group, but was at an approximately normal level in the long-term group. Pancreatic glucagon response to intravenous arginine, however, remained unchanged in both groups. Interruption of the enteroinsular axis as the result of massive bowel resection probably plays a major part in this discrepancy of the behaviour of insulin in the long-term group.
对13例接受了大范围肠切除手术的患者的胰腺内分泌功能进行了研究。患者被分为两组：术后1个月（短期组）和术后3个月或更长时间（长期组）。口服葡萄糖几乎在所有患者中都导致胰岛素分泌持续偏低，并且糖耐量曲线在4例患者中呈糖尿病模式。相比之下，短期组对静脉输注精氨酸的胰岛素反应受损，但长期组的胰岛素反应处于大致正常水平。然而，两组对静脉注射精氨酸的胰高血糖素反应均保持不变。大范围肠切除导致肠-胰岛轴中断可能在长期组胰岛素行为的这种差异中起主要作用。
