Besterman H S, Adrian T E, Mallinson C N, Christofides N D, Sarson D L, Pera A, Lombardo L, Modigliani R, Bloom S R
Gut. 1982 Oct;23(10):854-61. doi: 10.1136/gut.23.10.854.
To investigate the possible role of gut and pancreatic hormones in the adaptive responses to gut resection, plasma concentrations of the circulating hormones were measured, in response to a test breakfast, in patients with either small or large intestinal resection and in healthy control subjects. In 18 patients with partial ileal resection a significant threefold rise was found in basal and postprandial levels of pancreatic polypeptide, a fourfold increase in motilin, and more than a twofold increase in gastrin and enteroglucagon levels compared with healthy controls. In contrast, nine patients with colonic resection had a threefold rise in levels of pancreatic polypeptide only. One or more of these peptides may have a role in stimulating the adaptive changes found after gut resection.
为研究肠道和胰腺激素在肠道切除适应性反应中的可能作用，对小肠或大肠切除患者及健康对照者在进食试验早餐后测定了循环激素的血浆浓度。在18例部分回肠切除患者中，发现胰腺多肽的基础水平和餐后水平显著升高三倍，胃动素升高四倍，胃泌素和肠高血糖素水平升高两倍多，与健康对照者相比有显著差异。相比之下，9例结肠切除患者仅胰腺多肽水平升高三倍。这些肽中的一种或多种可能在刺激肠道切除后出现的适应性变化中起作用。
