Turton J A, Hicks R M, Gwynne J, Hunt R, Hawkey C M
Ciba Found Symp. 1985;113:220-51. doi: 10.1002/9780470720943.ch13.
The long-term effects of N-ethylretinamide (NER) on the haematology of the rat, and the dose-related effects of retinoids on lymphoid organs of the mouse and rat were investigated. Retinoid-induced long-bone changes were used to develop a method for quantifying skeletal effects. This technique was used to investigate the activity of five retinamides in inducing long-bone changes in the rat. The ability of non-steroidal anti-inflammatory compounds (NSAICs) to prevent retinoid-induced skeletal effects was examined, and preliminary investigations made into the mechanisms of retinoid-induced long-bone remodelling. NER-fed rats had reduced red blood cell counts and fibrinogen values. Retinoids caused dose-related proliferation of the spleen and lymph nodes in the mouse and to a lesser extent in the rat. They induced dose-related reductions in femoral diaphysis and medullary cavity diameters in both rats and mice. Aspirin prevented NER-induced changes of rat long bones, but subsequent studies indicated this effect may be closely dependent on the dose level of both the retinoid and NSAIC administered. Retinoids induce rapid long-bone remodelling in the rat which tends to revert on feeding a control diet, but remodelling processes are different in the young growing rat and the mature animal.
研究了N-乙基视黄酰胺（NER）对大鼠血液学的长期影响，以及类视黄醇对小鼠和大鼠淋巴器官的剂量相关影响。利用类视黄醇诱导的长骨变化开发了一种量化骨骼效应的方法。该技术用于研究五种视黄酰胺在诱导大鼠长骨变化方面的活性。研究了非甾体抗炎化合物（NSAICs）预防类视黄醇诱导的骨骼效应的能力，并对类视黄醇诱导长骨重塑的机制进行了初步研究。喂食NER的大鼠红细胞计数和纤维蛋白原值降低。类视黄醇导致小鼠脾脏和淋巴结出现剂量相关的增殖，在大鼠中程度较轻。它们在大鼠和小鼠中均诱导股骨骨干和髓腔直径出现剂量相关的减小。阿司匹林可预防NER诱导的大鼠长骨变化，但后续研究表明，这种效应可能紧密依赖于所给予的类视黄醇和NSAIC的剂量水平。类视黄醇在大鼠中诱导快速的长骨重塑，在喂食对照饮食时这种重塑倾向于恢复，但幼龄生长大鼠和成年动物的重塑过程有所不同。
