School of Pharmacy, Changchun University of Chinese Medicine, Jilin, Changchun, 130000, China.
J Ethnopharmacol. 2024 Oct 5;332:118324. doi: 10.1016/j.jep.2024.118324. Epub 2024 May 14.
Belamcanda chinensis (L.) Redouté is widely distributed in East Asia, such as China, Russia and North Korea. Belamcandae Rhizoma is the sun-dried rhizome of B. chinensis and has a long history of traditional medicinal use. It was first recorded in the Shennong's Herbal Classic, and has the effects of clearing heat and detoxifying, eliminating phlegm and benefiting the pharynx.
To systematically study the source of Belamcandae Rhizoma, summarize the evolution of its medicinal properties, efficacy and the application history of its prescriptions, summarize its biological activity, phytochemistry, synthetic metabolic pathway and toxicology, and screen the Quality-Markers of Belamcandae Rhizoma according to the screening principle of traditional Chinese medicine Quality-Markers.
All information available on Belamcandae Rhizoma was collected using electronic search engines, such as Pubmed, Web of Science, CNKI, WFO (www.worldfloraonline.org), MPNS (https://mpsn.kew.org), Changchun University of Traditional Chinese Medicine Library collections, Chinese Medical Classics.
The source of Belamcandae Rhizoma is B. chinensis of Iridaceae. It has a long history of application in China. It has the effects of clearing heat and detoxifying, eliminating phlegm and promoting pharynx. Modern pharmacological studies have shown that it has anti-inflammatory, anti-oxidation, anti-tumor and other physiological activities, and is safe and non-toxic at normal application doses. At present, tectoridin, iridin, tectorigenin, irigenin and irisflorentin are identified as the Quality-Markers of Belamcandae Rhizoma.
As a traditional Chinese medicine, Belamcandae Rhizoma has a long history of application, and multifaceted studies have demonstrated that Belamcandae Rhizoma is a promising Chinese medicine with good application prospects. By reviewing and identifying the Quality-Markers of Belamcandae Rhizoma, this study can help to establish the evaluation procedure of it on the one hand, and identify the shortcomings research on the other hand. Currently, there are few studies on the anabolism and toxicology of it, and future studies may focus on its in vivo processes, toxicology and adverse effects.
射干（Belamcanda chinensis（L.）Redouté）广泛分布于东亚地区，如中国、俄罗斯和朝鲜。射干根茎是射干的干燥根茎，具有悠久的传统药用历史。它最早记载于《神农本草经》，具有清热解毒、祛痰利咽的功效。
系统研究射干根茎的来源，总结其药性、功效及方剂应用历史，总结其生物活性、植物化学、合成代谢途径及毒理学，按照中药质量标志物的筛选原则筛选射干根茎的质量标志物。
利用 Pubmed、Web of Science、CNKI、WFO（www.worldfloraonline.org）、MPNS（https://mpsn.kew.org）、长春中医药大学图书馆馆藏、中国医学经典等电子搜索引擎收集射干根茎的所有信息。
射干根茎的来源为鸢尾科射干（B. chinensis）。在中国应用历史悠久，具有清热解毒、祛痰利咽的功效。现代药理研究表明，具有抗炎、抗氧化、抗肿瘤等生理活性，在正常应用剂量下安全无毒。目前，鉴定出鸢尾苷、鸢尾苷元、鸢尾甲黄素、鸢尾黄素和鸢尾苷元为射干根茎的质量标志物。
作为一种传统中药，射干根茎应用历史悠久，多方面的研究表明，射干根茎是一种具有良好应用前景的有前途的中药。通过对射干根茎质量标志物的评价和鉴定，一方面可以帮助建立其评价程序，另一方面可以发现研究的不足之处。目前，对其代谢和毒理学的研究较少，未来的研究可能集中在其体内过程、毒理学和不良反应上。
