School of Chemical Engineering, Yeungnam University, 280-Daehak-ro, Gyeongsan 38541, Republic of Korea.
School of Chemical Engineering, Yeungnam University, 280-Daehak-ro, Gyeongsan 38541, Republic of Korea.
Int J Biol Macromol. 2024 Jun;271(Pt 2):132374. doi: 10.1016/j.ijbiomac.2024.132374. Epub 2024 May 15.
The controlled delivery of the desired bioactive molecules is required to achieve the maximum therapeutic effects with minimum side effects. Biopolymer-based hydrogels are ideal platforms for delivering the desired molecules owing to their superior biocompatibility, biodegradability, and low-immune response. However, the prolonged delivery of the drugs through biopolymer-based hydrogels is restricted due to their weak mechanical stability. We developed mechanically tough and biocompatible hydrogels to address these limitations using carboxymethyl chitosan, sodium alginate, and nanocellulose for sustained drug delivery. The hydrogels were cross-linked through calcium ions to enhance their mechanical strength. Nanocellulose-added hydrogels exhibited improved mechanical strength (Young's modulus; 23.36 → 30.7 kPa, Toughness; 1.39 → 5.65 MJm) than pure hydrogels. The composite hydrogels demonstrated increased recovery potential (66.9 → 84.5 %) due to the rapid reformation of damaged polymeric networks. The hydrogels were stable in an aqueous medium and demonstrated reduced swelling potential. The hydrogels have no adverse effects on embryonic murine fibroblast (3 T3), showing their biocompatibility. No bacterial growth was observed in hydrogels-treated groups, indicating their antibacterial characteristics. The sustained drug released was observed from nanocellulose-assisted hydrogel scaffolds compared to the pure polymer hydrogel scaffold. Thus, hydrogels have potential and could be used as a sustained drug carrier.
为了实现最大的治疗效果和最小的副作用，需要控制所需生物活性分子的递送。基于生物聚合物的水凝胶是递送所需分子的理想平台，因为它们具有优异的生物相容性、生物可降解性和低免疫反应性。然而，由于其机械强度较弱，基于生物聚合物的水凝胶限制了药物的延长递送。我们使用羧甲基壳聚糖、海藻酸钠和纳米纤维素开发了机械强度高且生物相容的水凝胶，以解决这些限制，用于持续药物递送。水凝胶通过钙离子交联以增强其机械强度。与纯水凝胶相比，添加纳米纤维素的水凝胶表现出更高的机械强度（杨氏模量；23.36→30.7kPa，韧性；1.39→5.65MJm）。由于受损聚合物网络的快速重构，复合水凝胶表现出更高的恢复潜力（66.9→84.5%）。水凝胶在水介质中稳定，表现出较低的溶胀潜力。水凝胶对胚胎鼠成纤维细胞（3T3）没有不良影响，显示出其生物相容性。在水凝胶处理组中没有观察到细菌生长，表明其具有抗菌特性。与纯聚合物水凝胶支架相比，纳米纤维素辅助水凝胶支架观察到持续释放药物。因此，水凝胶具有潜力，可以用作持续药物载体。
