Am J Epidemiol. 2024 Sep 3;193(9):1233. doi: 10.1093/aje/kwae070.
The evidence from previous studies of serum 25-hydroxyvitamin D (25(OH)D) and ovarian cancer risk is not conclusive. However, the 25(OH)D levels were generally only measured in late adulthood, which may not capture the etiologically relevant exposure periods. We investigated predicted 25(OH)D over the adult lifetime in relation to ovarian cancer risk in a population-based case-control study conducted from 2011 to 2016 in Montreal, Canada (n = 490 cases and 896 controls). Predicted 25(OH)D was computed using previously validated regression models. Unconditional multivariable logistic regression models were used to estimate adjusted odds ratios (aORs) and 95% CIs for average predicted 25(OH)D over the adult lifetime and ovarian cancer risk. In addition, the relative importance of different periods of past 25(OH)D exposure was explored using a weighted cumulative exposure (WCE) model. For each 20-nmol/L increase in average predicted 25(OH)D over the adult lifetime, the aOR (95% CI) was 0.73 (0.55-0.96). In WCE analyses, the inverse association was strongest for exposures 5 to 20 years and 35 to 55 years prior to diagnosis, with aORs (95% CIs) of 0.82 (0.69-0.94) and 0.79 (0.66-1.02), respectively, for each 20-nmol/L increase in predicted 25(OH)D. These results support an inverse association between 25(OH)D levels in adulthood and ovarian cancer risk. This article is part of a Special Collection on Gynecological Cancers.
先前关于血清 25-羟维生素 D（25(OH)D）与卵巢癌风险的研究证据并不确定。然而，25(OH)D 水平通常仅在成年后期测量，这可能无法捕捉到与病因相关的暴露期。我们在 2011 年至 2016 年期间在加拿大蒙特利尔进行的一项基于人群的病例对照研究中，调查了成年期 25(OH)D 预测值与卵巢癌风险的关系（病例 490 例，对照 896 例）。使用先前验证的回归模型计算预测的 25(OH)D。使用非条件多变量逻辑回归模型来估计平均成年期预测 25(OH)D 与卵巢癌风险的调整比值比（aOR）和 95%置信区间。此外，使用加权累积暴露（WCE）模型探讨了不同时期过去 25(OH)D 暴露的相对重要性。与平均成年期预测 25(OH)D 每增加 20 纳摩尔/升相比，aOR（95%CI）为 0.73（0.55-0.96）。在 WCE 分析中，与诊断前 5 至 20 年和 35 至 55 年的暴露相比，逆关联最强，预测 25(OH)D 每增加 20 纳摩尔/升的 aOR（95%CI）分别为 0.82（0.69-0.94）和 0.79（0.66-1.02）。这些结果支持成年期 25(OH)D 水平与卵巢癌风险之间的负相关关系。本文是妇科癌症特刊的一部分。
