Marquis Flavie, Ritonja Jennifer A, Gariépy Geneviève, Koushik Anita
Université de Montréal Hospital Research Centre (CRCHUM), Montreal, QC, Canada.
Department of Social and Preventive Medicine, Université de Montréal, Montreal, QC, Canada.
Cancer Causes Control. 2025 Sep 4. doi: 10.1007/s10552-025-02061-9.
Variations in sleep duration have been linked to biological mechanisms that may affect cancer risk. We investigated the association between sleep duration during adult life and the risk of epithelial ovarian cancer overall, and according to tumor behavior and invasive cancer type, in a population-based case-control study.
Among 465 cases and 855 controls, sleep duration during life periods starting at age 20 years was assessed, with which average sleep during adult life was calculated. Unconditional multivariable logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Polytomous logistic regression was used to estimate associations by tumor behavior (invasive vs. borderline) and invasive cancer type (Type I vs. II).
Compared to an average sleep duration during adult life of the recommended 7-9 h/night, the ORs (95% CI) for ovarian cancer overall were 1.04 (0.74-1.46) and 1.78 (1.15-2.75) for < 7 and > 9 h/night, respectively. An increased risk with > 9 h/night was also observed for invasive and borderline tumors and among Type I and Type II invasive cancer types.
The results suggest that sleep durations longer than the recommended 7-9 h/night during adulthood may be associated with an increased ovarian cancer risk.
睡眠时间的变化与可能影响癌症风险的生物学机制有关。在一项基于人群的病例对照研究中，我们调查了成年期睡眠时间与上皮性卵巢癌总体风险之间的关联，并根据肿瘤行为和浸润性癌症类型进行了分析。
在465例病例和855例对照中，评估了从20岁开始各时间段的睡眠时间，并据此计算成年期的平均睡眠时间。采用无条件多变量逻辑回归来估计比值比（OR）和95%置信区间（CI）。采用多分类逻辑回归来估计肿瘤行为（浸润性与交界性）和浸润性癌症类型（I型与II型）之间的关联。
与成年期平均睡眠时间为推荐的每晚7 - 9小时相比，每晚睡眠时间<7小时和>9小时的卵巢癌总体OR（95%CI）分别为1.04（0.74 - 1.46）和1.78（1.15 - 2.75）。对于浸润性和交界性肿瘤以及I型和II型浸润性癌症类型，每晚睡眠时间>9小时也观察到风险增加。
结果表明，成年期睡眠时间超过推荐的每晚7 - 9小时可能与卵巢癌风险增加有关。
