Sood Anubhuti, Raghavan Sreevatsan, Mishra Deepika, Priya Harsh
Translational Health Science and Technology Institute, Faridabad, India.
Division of Oral Pathology and Microbiology, Centre for Dental Education and Research, All India Institute of Medical Sciences, Delhi, India.
Evid Based Dent. 2024 Sep;25(3):168. doi: 10.1038/s41432-024-01014-6. Epub 2024 May 16.
SARS-CoV-2 virus and its variants continue to be on a rampage worldwide. Several vaccines are being marketed to control their spread and reduce severity of symptoms in the affected. Various adverse events are being reported following the vaccine administration and therefore this systematic review investigated the oral adverse events post-COVID-19 vaccination.
A systematic search of five databases was conducted. Case reports, case series and observational studies describing oral lesions/oral adverse effects (outcome) following anti-SARS-CoV-2 vaccination (exposure) in humans were included. Quality assessment of the studies was done using Joanna Briggs Institute Critical Appraisal tools. A working classification was developed from reported final diagnosis.
The systematic review included 18 individual cases. Majority of oral lesions occurred following BNT162b2 vaccination with average age of occurrence at 59.94 years. 67% of the affected individuals were female, with hypertension being the most common comorbidity.
Immune-mediated oral events have a propensity of occurrence following COVID-19 vaccination. mRNA-based vaccinations may have an affinity for causing oral adverse effects. It might be due to the immune dysregulation caused by these vaccinations.
The female, geriatric population and older individuals with co-morbidities might have an increased affinity to develop oral lesions post-COVID-19 vaccination.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒及其变种仍在全球肆虐。目前有几种疫苗正在上市，以控制其传播并减轻感染者的症状严重程度。疫苗接种后报告了各种不良事件，因此本系统评价调查了新冠病毒疫苗接种后的口腔不良事件。
对五个数据库进行了系统检索。纳入了描述人类接种抗SARS-CoV-2疫苗（暴露）后口腔病变/口腔不良反应（结果）的病例报告、病例系列和观察性研究。使用乔安娜·布里格斯研究所的批判性评价工具对研究进行质量评估。根据报告的最终诊断制定了一个工作分类。
该系统评价纳入了18个个体病例。大多数口腔病变发生在接种BNT162b2疫苗之后，发病的平均年龄为59.94岁。67%的受影响个体为女性，高血压是最常见的合并症。
新冠病毒疫苗接种后有发生免疫介导的口腔事件的倾向。基于信使核糖核酸的疫苗可能更容易引起口腔不良反应。这可能是由于这些疫苗引起的免疫失调。
女性、老年人群以及患有合并症的老年人在新冠病毒疫苗接种后可能更容易出现口腔病变。
