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纳米尺度金属有机骨架:为癌症治疗及其他领域开辟变革之路。

Nanoscaled metal-organic frameworks: charting a transformative path for cancer therapeutics and beyond.

机构信息

Advanced Porous Materials Unit, IMDEA Energy Institute, Av. Ramón de la Sagra 3, 28935, Madrid, Spain.

出版信息

Drug Deliv Transl Res. 2024 Aug;14(8):2041-2045. doi: 10.1007/s13346-024-01622-w. Epub 2024 May 16.

DOI:10.1007/s13346-024-01622-w
PMID:38755501
Abstract

Through this inspirational note, we would like to highlight the potential of nanoscaled metal-organic frameworks within the biomedical field. The unique properties of these materials that make them promising candidates for new nanomedicines are assessed here as well as the progression reached so far for combinational cancer therapies and theranostic, along with its most recent advances in nanomedicine. Finally, the perspective and challenges of these materials within this field is discussed.

摘要

通过这封鼓舞人心的便笺,我们希望强调纳米尺度金属有机骨架在生物医学领域的潜力。本文评估了这些材料的独特性质,这些性质使它们成为新型纳米药物的有前途的候选物,以及它们在组合癌症治疗和治疗诊断方面迄今为止的进展,以及纳米医学的最新进展。最后,讨论了这些材料在该领域的前景和挑战。

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Drug Deliv Transl Res. 2024 Aug;14(8):2041-2045. doi: 10.1007/s13346-024-01622-w. Epub 2024 May 16.
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本文引用的文献

1
Nanoscale Metal-Organic Framework with an X-ray Triggerable Prodrug for Synergistic Radiotherapy and Chemotherapy.具有 X 射线触发前药的纳米级金属有机框架用于协同放化疗
J Am Chem Soc. 2023 Aug 30;145(34):18698-18704. doi: 10.1021/jacs.3c04602. Epub 2023 Aug 15.
2
Mineralized Porphyrin Metal-Organic Framework for Improved Tumor Elimination and Combined Immunotherapy.矿化卟啉金属有机框架用于改善肿瘤消除和联合免疫治疗。
ACS Nano. 2023 Jul 11;17(13):12471-12482. doi: 10.1021/acsnano.3c02126. Epub 2023 Jun 26.
3
Laser-Induced Combinatorial Chemotherapeutic, Chemodynamic, and Photothermal Therapy for Hepatocellular Carcinoma Based on Oxaliplatin-Loaded Metal-Organic Frameworks.
基于载奥沙利铂金属有机框架的激光诱导组合化学治疗、化学动力学和光热治疗肝癌。
ACS Appl Mater Interfaces. 2023 Jan 25;15(3):3781-3790. doi: 10.1021/acsami.2c19305. Epub 2023 Jan 11.
4
Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy.基于多功能金属有机骨架(MOF)的纳米平台用于癌症治疗:从单一治疗到联合治疗。
Theranostics. 2023 Jan 1;13(1):295-323. doi: 10.7150/thno.80687. eCollection 2023.
5
Metal organic framework-based antibacterial agents and their underlying mechanisms.基于金属有机骨架的抗菌剂及其作用机制。
Chem Soc Rev. 2022 Aug 15;51(16):7138-7169. doi: 10.1039/d2cs00460g.
6
Chemodynamic and Photothermal Combination Therapy Based on Dual-Modified Metal-Organic Framework for Inducing Tumor Ferroptosis/Pyroptosis.基于双修饰金属有机框架的化学动力学和光热联合疗法诱导肿瘤铁死亡/细胞焦亡。
ACS Appl Mater Interfaces. 2022 Jun 1;14(21):24089-24101. doi: 10.1021/acsami.2c00574. Epub 2022 May 19.
7
A multimodal Metal-Organic framework based on unsaturated metal site for enhancing antitumor cytotoxicity through Chemo-Photodynamic therapy.一种基于不饱和金属位点的多模态金属有机框架,用于通过化学-光动力疗法增强抗肿瘤细胞毒性。
J Colloid Interface Sci. 2022 Sep;621:180-194. doi: 10.1016/j.jcis.2022.04.078. Epub 2022 Apr 15.
8
Synergistic checkpoint-blockade and radiotherapy-radiodynamic therapy via an immunomodulatory nanoscale metal-organic framework.通过免疫调节纳米级金属有机骨架实现协同检查点阻断和放射治疗-放射动力学治疗。
Nat Biomed Eng. 2022 Feb;6(2):144-156. doi: 10.1038/s41551-022-00846-w. Epub 2022 Feb 21.
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Independent Drug Action in Combination Therapy: Implications for Precision Oncology.联合治疗中的独立药物作用:对精准肿瘤学的影响。
Cancer Discov. 2022 Mar 1;12(3):606-624. doi: 10.1158/2159-8290.CD-21-0212.
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ACS Appl Mater Interfaces. 2021 Dec 8;13(48):56972-56987. doi: 10.1021/acsami.1c18053. Epub 2021 Nov 19.