Xu Peiye, He Jiaxuan, Xu Ting, Wang Weijie, Wu Baihui, Chen Rongbing, Wang Hanbing, Yang Qinsi, Wu Wei, Sun Da
Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou 325035, China.
School of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.
Theranostics. 2025 Jul 28;15(16):8609-8638. doi: 10.7150/thno.113474. eCollection 2025.
The combination of extracellular vesicles (EVs) and metal-organic frameworks (MOFs) is a cutting-edge strategy in nanomedicine, leveraging the immune evasion, targeting capabilities, and biocompatibility of EVs with the high loading capacity and tunable functionality of MOFs. This review comprehensively discusses the latest advancements in the EV-MOF collaborative system, including its combined form and preparation process, focusing on its synergistic applications in disease diagnosis and treatment. EV-MOF platforms have demonstrated enhanced sensitivity in biosensing and bioimaging, offering new avenues for early cancer detection using signal amplification and fluorescence imaging technologies. Therapeutically, EV-MOF systems have demonstrated significant promise in drug delivery, cancer treatment, rheumatoid arthritis, ulcerative colitis, wound healing, bone regeneration, and anti-infection applications, delivering targeted therapies with controlled drug release, and improved biocompatibility. Despite these advancements, challenges remain in optimizing the binding methods between EVs and MOFs, ensuring their stability, and understanding their mechanisms. Addressing these may be key to unlocking the full clinical potential of EV-MOF systems. This review provides a critical analysis of the current state of research, offering insights and guidance for future exploration in this rapidly evolving field.
细胞外囊泡（EVs）与金属有机框架（MOFs）的结合是纳米医学中的一种前沿策略，它利用了EVs的免疫逃逸、靶向能力和生物相容性以及MOFs的高负载能力和可调节功能。本文综述全面讨论了EV-MOF协同系统的最新进展，包括其组合形式和制备过程，重点关注其在疾病诊断和治疗中的协同应用。EV-MOF平台在生物传感和生物成像方面表现出更高的灵敏度，利用信号放大和荧光成像技术为早期癌症检测提供了新途径。在治疗方面，EV-MOF系统在药物递送、癌症治疗、类风湿性关节炎、溃疡性结肠炎、伤口愈合、骨再生和抗感染应用中显示出巨大潜力，能够实现可控药物释放的靶向治疗，并提高生物相容性。尽管取得了这些进展，但在优化EVs与MOFs之间的结合方法、确保其稳定性以及了解其作用机制方面仍存在挑战。解决这些问题可能是释放EV-MOF系统全部临床潜力的关键。本文综述对当前研究现状进行了批判性分析，为这一快速发展领域的未来探索提供了见解和指导。
