Owhashi M, Nawa Y
Infect Immun. 1985 Sep;49(3):533-7. doi: 10.1128/iai.49.3.533-537.1985.
Infection of mice with Schistosoma japonicum engendered high levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) in serum. The rise in GM-CSF levels in serum was closely associated with the acute phase of the infection and seemed to be dependent on the dose of infection. GM-CSF activity was detected as a sharp single peak in DE-52 anion-exchange chromatography and Sephacryl S-200 and Sephadex G-200 gel chromatography and was almost entirely adsorbed to concanavalin A-Sepharose 4B affinity chromatography. The possible immunological and immunopathological importance of GM-CSF in S. japonicum infection is discussed.
用日本血吸虫感染小鼠可使血清中粒细胞巨噬细胞集落刺激因子（GM-CSF）水平升高。血清中GM-CSF水平的升高与感染的急性期密切相关，且似乎取决于感染剂量。在DE-52阴离子交换色谱、Sephacryl S-200和Sephadex G-200凝胶色谱中，GM-CSF活性检测为一个尖锐的单峰，并且几乎完全吸附于伴刀豆球蛋白A-琼脂糖4B亲和色谱。本文讨论了GM-CSF在日本血吸虫感染中可能的免疫和免疫病理重要性。
