Li Xiaojing, Huang Zijie, Tian Yueqin, Chen Xing, Wu Haidong, Wang Tong
Department of Emergency, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.
Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Front Psychol. 2024 May 2;15:1305570. doi: 10.3389/fpsyg.2024.1305570. eCollection 2024.
With increased life expectancy, cognitive decline has emerged as a prevalent neurodegenerative disorder.
This study aimed to examine the correlation between concentrations of Plasma long-chain n-3 polyunsaturated fatty acids (LCPUFAs) and cognitive performance in elderly Americans.
Data were analyzed from older adults enrolled in two NHANES cycles. Participants completed four cognitive assessments, including the Immediate Recall Test (IRT), Delayed Recall Test (DRT), Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST). Linear regression and restricted cubic spline modeling examined associations between plasma LCPUFAs levels and cognitive test outcomes.
The cohort included 610 adults aged 69 years on average, 300 (49.2%) males and 310 (50.8%) females. The median LCPUFAs concentration was 309.4 μmol/L, with an interquartile range of 244.7-418.9 μmol/L. In unadjusted and adjusted generalized linear regression model analyses, circulating LCPUFAs exhibited significant positive correlations with DRT performance. No relationships were detected among those with chronic conditions (chronic heart failure, stroke, diabetes). A significant association between LCPUFAs levels and DRT scores was evident in males but not females.
Plasma LCPUFAs concentrations were significantly associated with DRT performance in males free of chronic illnesses, including heart failure, stroke, and diabetes.
随着预期寿命的延长，认知衰退已成为一种普遍的神经退行性疾病。
本研究旨在探讨美国老年人血浆长链n-3多不饱和脂肪酸（LCPUFAs）浓度与认知表现之间的相关性。
对参加两个国家健康与营养检查调查（NHANES）周期的老年人的数据进行分析。参与者完成了四项认知评估，包括即时回忆测试（IRT）、延迟回忆测试（DRT）、动物流畅性测试（AFT）和数字符号替换测试（DSST）。线性回归和受限立方样条建模检查了血浆LCPUFAs水平与认知测试结果之间的关联。
该队列包括610名成年人，平均年龄69岁，男性300名（49.2%），女性310名（50.8%）。LCPUFAs浓度中位数为309.4μmol/L，四分位间距为244.7 - 418.9μmol/L。在未调整和调整后的广义线性回归模型分析中，循环LCPUFAs与DRT表现呈显著正相关。在患有慢性疾病（慢性心力衰竭、中风、糖尿病）的人群中未检测到相关性。LCPUFAs水平与DRT分数之间的显著关联在男性中明显，但在女性中不明显。
在没有慢性疾病（包括心力衰竭、中风和糖尿病）的男性中，血浆LCPUFAs浓度与DRT表现显著相关。
