Department of General Practice, Beijing TianTan Hospital, Capital Medical University, Beijing, China.
Department of Pulmonary and Critical Care Medicine, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
PLoS One. 2024 Sep 27;19(9):e0310546. doi: 10.1371/journal.pone.0310546. eCollection 2024.
Arthritis has been postulated as a prevalent potential risk factor for the emergence of dementia and cognitive impairment. This conjecture prompted an examination of the correlation between arthritis and cognitive impairment using the National Health and Nutrition Examination Survey (NHANES) repository. The analysis was meticulously adjusted for potential confounders such as age and assorted systemic comorbidities, to ensure robustness in the results obtained.
Among 2,398 adults aged 60 years and above, logistic regression and cubic spline models were employed to elucidate the relationship between arthritis and cognitive performance. This was assessed utilizing tests such as Immediate Recall test (IRT), Delayed Recall test (DRT), Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST).
In our investigation, a total of 19931 individuals were analyzed, among which 2,398 patients (12.03%) were identified with arthritis. Subjects with arthritis inflammation had lower DSST and AFT scores compared to the healthy group, indicating cognitive decline. After adjusting for all covariates, arthritis was significantly associated with higher DSST and AFT scores by logistic regression modeling (OR: 0.796, 95% CI: 0.649-0.975; OR: 0.769, 95% CI: 0.611-0.968).
Our analysis underscores the potential linkage between arthritis prevalence and cognitive impairment within a nationally representative of US older adults.
关节炎被认为是痴呆和认知障碍出现的普遍潜在危险因素。这一推测促使我们利用国家健康和营养调查（NHANES）数据库研究关节炎与认知障碍之间的相关性。分析对年龄和各种系统性合并症等潜在混杂因素进行了细致的调整，以确保结果的稳健性。
在 2398 名 60 岁及以上的成年人中，采用逻辑回归和三次样条模型来阐明关节炎与认知表现之间的关系。使用即时回忆测试（IRT）、延迟回忆测试（DRT）、动物流畅性测试（AFT）和数字符号替代测试（DSST）等测试来评估这一点。
在我们的研究中，共分析了 19931 人，其中 2398 人（12.03%）患有关节炎。有炎症性关节炎的患者的 DSST 和 AFT 评分低于健康组，表明认知能力下降。在调整所有协变量后，逻辑回归模型表明关节炎与较高的 DSST 和 AFT 评分显著相关（OR：0.796，95%CI：0.649-0.975；OR：0.769，95%CI：0.611-0.968）。
我们的分析强调了美国老年人群中关节炎患病率与认知障碍之间的潜在联系。
