State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, National Clinical Research Center for Infectious Diseases, Zhejiang University, No. 79 Qingchun Road, Shangcheng District, 310003, Hangzhou, China.
Department of Neurosurgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China.
Mol Cancer. 2022 May 5;21(1):108. doi: 10.1186/s12943-022-01582-0.
CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway. Aberrant Wnt pathway activation is involved in the development of various types of cancers. Accumulating evidence indicates that the circRNA/Wnt axis modulates the expression of cancer-associated genes and then regulates cancer progression. Wnt pathway-related circRNA expression is obviously associated with many clinical characteristics. CircRNAs could regulate cell biological functions by interacting with the Wnt pathway. Moreover, Wnt pathway-related circRNAs are promising potential biomarkers for cancer diagnosis, prognosis evaluation, and treatment. In our review, we summarized the recent research progress on the role and clinical application of Wnt pathway-related circRNAs in tumorigenesis and progression.
CircRNAs，即共价闭合的非编码 RNA，广泛存在于从病毒到植物到哺乳动物等多种物种中。CircRNAs 在 Wnt 通路中富集。异常的 Wnt 通路激活参与了多种类型癌症的发生。越来越多的证据表明，circRNA/Wnt 轴调节癌基因的表达，进而调节癌症的进展。与 Wnt 通路相关的 circRNA 表达与许多临床特征明显相关。CircRNAs 可以通过与 Wnt 通路相互作用来调节细胞的生物学功能。此外，与 Wnt 通路相关的 circRNAs 是癌症诊断、预后评估和治疗有前途的潜在生物标志物。在我们的综述中，我们总结了 Wnt 通路相关 circRNAs 在肿瘤发生和进展中的作用及其临床应用的最新研究进展。
