Department of Biological Sciences, University of Toronto Scarborough, Toronto, ON, M1C 1A4, Canada.
Department of Cell and Systems Biology, University of Toronto, Toronto, ON, M5S 3G5, Canada.
New Phytol. 2024 Jul;243(1):48-57. doi: 10.1111/nph.19815. Epub 2024 May 17.
Recent advancements in our understanding of cell membrane dynamics have shed light on the importance of plasma membrane (PM) nanodomains in plant cell signaling. Nevertheless, many aspects of membrane nanodomains, including their regulatory mechanisms and biological functions, remain enigmatic. To address this knowledge gap, our review article proposes a novel perspective wherein signaling pathways target endoplasmic reticulum (ER)-based lipid metabolism to exert control over the formation and function of membrane nanodomains. Subsequently, these nanodomains reciprocate by influencing the localization and activity of signaling molecules at the PM. We place a specific emphasis on ER-based enzymatic reactions, given the ER's central role in membrane lipid biosynthesis and its capacity to directly impact PM lipid composition, particularly with regard to saturation levels - an essential determinant of nanodomain properties. The interplay among cell signaling, glycerolipid metabolism, and PM nanodomain may create feedforward/feedback loops that fine-tune cellular responses to developmental and environmental cues.
近年来，我们对细胞膜动力学的理解取得了进展，这揭示了质膜（PM）纳米域在植物细胞信号转导中的重要性。然而，膜纳米域的许多方面，包括其调节机制和生物学功能，仍然是个谜。为了弥补这一知识空白，我们的综述文章提出了一个新的观点，即信号通路靶向内质网（ER）为基础的脂质代谢，以控制膜纳米域的形成和功能。随后，这些纳米域通过影响 PM 上信号分子的定位和活性来产生反馈。我们特别强调基于 ER 的酶反应，因为 ER 在膜脂质生物合成中起着核心作用，并且能够直接影响 PM 脂质组成，特别是饱和水平——这是纳米域特性的一个重要决定因素。细胞信号转导、甘油磷脂代谢和 PM 纳米域之间的相互作用可能会形成正反馈/负反馈环，从而精细调节细胞对发育和环境信号的反应。
