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IFN-α/β/IFN-γ/IL-15 通路鉴定出具有免疫应答表型的 GBP1 表达肿瘤。

IFN-α/β/IFN-γ/IL-15 pathways identify GBP1-expressing tumors with an immune-responsive phenotype.

机构信息

Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, People's Republic of China.

Institute of Life Sciences, Chongqing Medical University, Chongqing, 400032, People's Republic of China.

出版信息

Clin Exp Med. 2024 May 17;24(1):102. doi: 10.1007/s10238-024-01328-w.

DOI:10.1007/s10238-024-01328-w
PMID:38758367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11101573/
Abstract

Immunotherapy is widely used in cancer treatment; however, only a subset of patients responds well to it. Significant efforts have been made to identify patients who will benefit from immunotherapy. Successful anti-tumor immunity depends on an intact cancer-immunity cycle, especially long-lasting CD8 T-cell responses. Interferon (IFN)-α/β/IFN-γ/interleukin (IL)-15 pathways have been reported to be involved in the development of CD8 T cells. And these pathways may predict responses to immunotherapy. Herein, we aimed to analyze multiple public databases to investigate whether IFN-α/β/IFN-γ/IL-15 pathways could be used to predict the response to immunotherapy. Results showed that IFN-α/β/IFN-γ/IL-15 pathways could efficiently predict immunotherapy response, and guanylate-binding protein 1 (GBP1) could represent the IFN-α/β/IFN-γ/IL-15 pathways. In public and private cohorts, we further demonstrated that GBP1 could efficiently predict the response to immunotherapy. Functionally, GBP1 was mainly expressed in macrophages and strongly correlated with chemokines involved in T-cell migration. Therefore, our study comprehensively investigated the potential role of GBP1 in immunotherapy, which could serve as a novel biomarker for immunotherapy and a target for drug development.

摘要

免疫疗法被广泛应用于癌症治疗；然而，只有一部分患者对此治疗方法反应良好。人们已经做出了巨大努力来识别将从免疫疗法中受益的患者。成功的抗肿瘤免疫取决于完整的癌症免疫循环，尤其是持久的 CD8 T 细胞反应。干扰素 (IFN)-α/β/IFN-γ/白细胞介素 (IL)-15 途径已被报道参与 CD8 T 细胞的发育。这些途径可能预测对免疫疗法的反应。在此，我们旨在分析多个公共数据库，以研究 IFN-α/β/IFN-γ/IL-15 途径是否可用于预测免疫疗法的反应。结果表明，IFN-α/β/IFN-γ/IL-15 途径可有效地预测免疫疗法的反应，而鸟苷酸结合蛋白 1 (GBP1) 可代表 IFN-α/β/IFN-γ/IL-15 途径。在公共和私人队列中，我们进一步证明 GBP1 可有效地预测免疫疗法的反应。在功能上，GBP1 主要在巨噬细胞中表达，并与参与 T 细胞迁移的趋化因子强烈相关。因此，我们的研究全面调查了 GBP1 在免疫疗法中的潜在作用，它可以作为免疫疗法的新型生物标志物和药物开发的靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c381/11101573/308ed00c2c8a/10238_2024_1328_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c381/11101573/ff27a9943318/10238_2024_1328_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c381/11101573/ee610c3e3fdd/10238_2024_1328_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c381/11101573/90fc48542e45/10238_2024_1328_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c381/11101573/b77fd5320f01/10238_2024_1328_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c381/11101573/d6f6fbd633b5/10238_2024_1328_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c381/11101573/308ed00c2c8a/10238_2024_1328_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c381/11101573/ff27a9943318/10238_2024_1328_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c381/11101573/ee610c3e3fdd/10238_2024_1328_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c381/11101573/90fc48542e45/10238_2024_1328_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c381/11101573/b77fd5320f01/10238_2024_1328_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c381/11101573/d6f6fbd633b5/10238_2024_1328_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c381/11101573/308ed00c2c8a/10238_2024_1328_Fig6_HTML.jpg

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