• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

CXCL9 和 CXCL10 为肿瘤带来炎症反应。

CXCL9 and CXCL10 bring the heat to tumors.

机构信息

Department of Pathology, University of Chicago, Chicago, IL, USA.

Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.

出版信息

Sci Immunol. 2022 Jul 22;7(73):eabq6509. doi: 10.1126/sciimmunol.abq6509.

DOI:10.1126/sciimmunol.abq6509
PMID:35867802
Abstract

CXCL9 and CXCL10 can be produced by antigen-presenting cells (dendritic cells or macrophages) and by tumor cells. Hoch demonstrated that CXCL9 and CXCL10 co-localize with LAG3 T cells expressing CCL4 or CXCL13 and contribute to the generation of a "hot" tumor microenvironment.

摘要

CXCL9 和 CXCL10 可以由抗原呈递细胞（树突状细胞或巨噬细胞）和肿瘤细胞产生。 Hoch 证明，CXCL9 和 CXCL10 与表达 CCL4 或 CXCL13 的 LAG3 T 细胞共定位，并有助于产生“热”肿瘤微环境。

相似文献

1
CXCL9 and CXCL10 bring the heat to tumors.CXCL9 和 CXCL10 为肿瘤带来炎症反应。
Sci Immunol. 2022 Jul 22;7(73):eabq6509. doi: 10.1126/sciimmunol.abq6509.
2
Interferon Epsilon Loss Is Elusive 9p21 Link to Immune-Cold Tumors, Resistant to Immune Checkpoint Therapy, and Endogenous CXCL9/10 Induction.干扰素ε缺失是9p21与免疫冷肿瘤、免疫检查点治疗耐药及内源性CXCL9/10诱导之间难以捉摸的联系。
J Thorac Oncol. 2024 Dec 24. doi: 10.1016/j.jtho.2024.12.020.
3
Chemokine signatures in the skin disorders of Lyme borreliosis in Europe: predominance of CXCL9 and CXCL10 in erythema migrans and acrodermatitis and CXCL13 in lymphocytoma.欧洲莱姆病皮肤疾病中的趋化因子特征：游走性红斑和肢端皮炎中CXCL9和CXCL10占主导，淋巴细胞瘤中CXCL13占主导。
Infect Immun. 2007 Sep;75(9):4621-8. doi: 10.1128/IAI.00263-07. Epub 2007 Jul 2.
4
CXC chemokine ligand (CXCL) 9 and CXCL10 are antagonistic costimulation molecules during the priming of alloreactive T cell effectors.CXC 趋化因子配体 (CXCL) 9 和 CXCL10 是在同种异体反应性 T 细胞效应器的激活过程中的拮抗共刺激分子。
J Immunol. 2010 Apr 1;184(7):3450-60. doi: 10.4049/jimmunol.0903831. Epub 2010 Mar 1.
5
Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10.异二聚体 IL-15 通过涉及 XCL1、IFN-γ、CXCL9 和 CXCL10 的细胞因子网络延迟肿瘤生长并促进肿瘤内 CTL 和树突状细胞积累。
J Immunother Cancer. 2020 May;8(1). doi: 10.1136/jitc-2020-000599.
6
The role of CXCL9, CXCL10, and CXCL13 chemokines in patients with Sjögren's syndrome.CXCL9、CXCL10和CXCL13趋化因子在干燥综合征患者中的作用。
Clin Rheumatol. 2025 Apr;44(4):1635-1642. doi: 10.1007/s10067-025-07367-2. Epub 2025 Feb 24.
7
Interferons induce CXCR3-cognate chemokine production by human metastatic melanoma.干扰素诱导人转移性黑色素瘤产生 CXCR3 同源趋化因子。
J Immunother. 2010 Nov-Dec;33(9):965-74. doi: 10.1097/CJI.0b013e3181fb045d.
8
Role of serum CXCL9 and CXCL13 in predicting infection after kidney transplant: A STROBE study.血清 CXCL9 和 CXCL13 在预测肾移植后感染中的作用：一项 STROBE 研究。
Medicine (Baltimore). 2021 Mar 19;100(11):e24762. doi: 10.1097/MD.0000000000024762.
9
The chemokines CXCL9 and CXCL10 promote a protective immune response but do not contribute to cardiac inflammation following infection with Trypanosoma cruzi.趋化因子CXCL9和CXCL10可促进保护性免疫反应，但在克氏锥虫感染后对心脏炎症并无影响。
Infect Immun. 2006 Jan;74(1):125-34. doi: 10.1128/IAI.74.1.125-134.2006.
10
CXCL9, CXCL10, and CXCL11; biomarkers of pulmonary inflammation associated with autoimmunity in patients with collagen vascular diseases-associated interstitial lung disease and interstitial pneumonia with autoimmune features.CXCL9、CXCL10 和 CXCL11；与胶原血管疾病相关的间质性肺疾病和具有自身免疫特征的间质性肺炎患者自身免疫相关肺部炎症的生物标志物。
PLoS One. 2020 Nov 2;15(11):e0241719. doi: 10.1371/journal.pone.0241719. eCollection 2020.

引用本文的文献

1
AEBP1 drives fibroblast-mediated T cell dysfunction in tumors.AEBP1驱动肿瘤中由成纤维细胞介导的T细胞功能障碍。
Nat Commun. 2025 Sep 1;16(1):8171. doi: 10.1038/s41467-025-63659-w.
2
Genetic liability to systemic inflammatory regulators is causally linked to COVID-19 diverse phenotypes: Insights from multi-omics association study and single-cell RNA sequencing analysis.全身炎症调节因子的遗传易感性与新冠病毒病的多种表型存在因果关系：多组学关联研究和单细胞RNA测序分析的见解
Medicine (Baltimore). 2025 Aug 22;104(34):e44089. doi: 10.1097/MD.0000000000044089.
3
Identification of Deregulated Proteins in Mutated / Breast and Ovarian Cancers for Vectorized Biologics.
用于载体化生物制剂的突变型乳腺癌和卵巢癌中失调蛋白的鉴定
Cancers (Basel). 2025 Jul 1;17(13):2208. doi: 10.3390/cancers17132208.
4
Enhanced immunotherapy response in lung adenocarcinoma patients with COPD: insights into tumor cells and immune microenvironment characteristics.慢性阻塞性肺疾病（COPD）患者的肺腺癌免疫治疗反应增强：对肿瘤细胞和免疫微环境特征的见解
Cell Commun Signal. 2025 Jul 4;23(1):324. doi: 10.1186/s12964-025-02332-7.
5
High-precision immune-related plasma proteomics profiling predicts response to immunotherapy in patients with triple-negative breast cancer.高精度免疫相关血浆蛋白质组学分析可预测三阴性乳腺癌患者对免疫治疗的反应。
Cancer Biol Med. 2025 Jul 4;22(7):854-70. doi: 10.20892/j.issn.2095-3941.2025.0038.
6
Application of single-cell and spatial omics in deciphering cellular hallmarks of cancer drug response and resistance.单细胞和空间组学在解读癌症药物反应和耐药性细胞特征中的应用。
J Hematol Oncol. 2025 Jul 2;18(1):70. doi: 10.1186/s13045-025-01722-1.
7
Comprehensive multi-omics and biochemical analysis to elucidate the molecular response mechanisms of gill and kidney tissues under acute salinity stress in Pseudobagras ussuriensis.综合多组学和生化分析以阐明乌苏里拟鲿在急性盐度胁迫下鳃和肾组织的分子反应机制。
BMC Genomics. 2025 Jul 1;26(1):590. doi: 10.1186/s12864-025-11773-w.
8
Enhanced antitumor immunity of VNP20009-CCL2-CXCL9 via the cGAS/STING axis in osteosarcoma lung metastasis.VNP20009-CCL2-CXCL9通过cGAS/STING轴增强骨肉瘤肺转移中的抗肿瘤免疫。
J Immunother Cancer. 2025 Jul 1;13(7):e012269. doi: 10.1136/jitc-2025-012269.
9
Engineered NIR-Responsive Exosomes for Synergistic Photoimmunotherapy of Hepatocellular Carcinoma.用于肝细胞癌协同光免疫治疗的工程化近红外响应性外泌体
ACS Omega. 2025 Jun 11;10(24):25675-25685. doi: 10.1021/acsomega.5c01396. eCollection 2025 Jun 24.
10
p95HER2, a truncated form of the HER2 oncoprotein, drives an immunosuppressive program in HER2 breast cancer that limits trastuzumab deruxtecan efficacy.p95HER2是HER2癌蛋白的一种截短形式，它在HER2阳性乳腺癌中驱动一种免疫抑制程序，限制了曲妥珠单抗德鲁昔康的疗效。
Nat Cancer. 2025 Jun 27. doi: 10.1038/s43018-025-00969-4.