CXCL9 和 CXCL10 为肿瘤带来炎症反应。
CXCL9 and CXCL10 bring the heat to tumors.
机构信息
Department of Pathology, University of Chicago, Chicago, IL, USA.
Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
出版信息
Sci Immunol. 2022 Jul 22;7(73):eabq6509. doi: 10.1126/sciimmunol.abq6509.
PMID:35867802
Abstract
CXCL9 and CXCL10 can be produced by antigen-presenting cells (dendritic cells or macrophages) and by tumor cells. Hoch demonstrated that CXCL9 and CXCL10 co-localize with LAG3 T cells expressing CCL4 or CXCL13 and contribute to the generation of a "hot" tumor microenvironment.
摘要
CXCL9 和 CXCL10 可以由抗原呈递细胞（树突状细胞或巨噬细胞）和肿瘤细胞产生。 Hoch 证明，CXCL9 和 CXCL10 与表达 CCL4 或 CXCL13 的 LAG3 T 细胞共定位，并有助于产生“热”肿瘤微环境。
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