Hamoudi A B, Little M, Newton W A, Heyn R, Lahey M E, Ladisch S, Leikin S, Neerhout R, Shore N, Smith B
Pediatr Pathol. 1985;3(1):93-102. doi: 10.3109/15513818509068839.
Histiocytosis X is characterized by the presence of cytoplasmic rod structures called Langerhans' cell granules or X granules (XG). It has been speculated that histiocytosis X is a Langerhans' cell disorder. This ultrastructural study was performed to quantitate the number of XG containing histiocytes in the histiocytosis X lesions. Twenty-four specimens from 22 patients with histiocytosis X were studied: 4 from skin, 5 from lymph node, 11 from bone, 2 from lung, 1 from gingiva, and 1 from cheek. The majority of the histiocytes in histiocytosis X lesions do not contain X granules. The majority of the histiocytes in histiocytosis X lesions do not contain X granules. The percentage of histiocytes with XG in a lesion has no relation to the age of the patient or the organ from which it was obtained, except for skin, where they were quite numerous. The relative percent-age of histiocytes with granules does not correlate significantly with the prognosis of these patients.
组织细胞增多症X的特征是存在被称为朗格汉斯细胞颗粒或X颗粒（XG）的细胞质杆状结构。据推测，组织细胞增多症X是一种朗格汉斯细胞疾病。进行这项超微结构研究是为了定量组织细胞增多症X病变中含XG的组织细胞数量。对22例组织细胞增多症X患者的24个标本进行了研究：4个来自皮肤，5个来自淋巴结，11个来自骨骼，2个来自肺，1个来自牙龈，1个来自脸颊。组织细胞增多症X病变中的大多数组织细胞不含X颗粒。组织细胞增多症X病变中的大多数组织细胞不含X颗粒。病变中含XG的组织细胞百分比与患者年龄或取材器官无关，但皮肤除外，皮肤中的XG数量较多。含颗粒组织细胞的相对百分比与这些患者的预后无显著相关性。
