Starling M R, Dehmer G J, Lancaster J L, Lasher J C, Walsh R A, Weiland F L, Uhl G S, Blumhardt R
Radiology. 1985 Oct;157(1):231-7. doi: 10.1148/radiology.157.1.3875879.
Normal quantitative circumferential profile limits were established for a 30 degrees bilateral rotating slant-hole (RSH) collimator tomographic system. This system's value in detecting segmental coronary artery disease was assessed in a study evaluating 196 patients by thallium 201 myocardial scintigraphy and coronary arteriography. Profile curves were calculated from images of 20 healthy patients and used to identify significant coronary artery disease (greater than or equal to 70% diameter narrowing) in the left anterior descending (LAD), the right, and the left circumflex (LCx) coronary arteries. In a group of 86 patients, an abnormality on the apical or middle plane optimally identified segmental coronary artery disease. When such abnormalities were prospectively evaluated in a test group of 110 patients, the sensitivity and specificity were 79% and 93% for LAD, 90% and 90% for right, and 83% and 83% for LCx coronary artery disease. Compared with qualitative interpretation of the planar and tomographic images, quantitative tomography significantly improved the sensitivity of T1-201 imaging in detecting LAD, right, and LCx coronary artery disease (P less than .001) in patients with or without previous myocardial infarction.
为一个30度双侧旋转斜孔（RSH）准直器断层摄影系统建立了正常的定量圆周轮廓限度。在一项通过铊201心肌闪烁显像和冠状动脉造影对196例患者进行评估的研究中，评估了该系统在检测节段性冠状动脉疾病方面的价值。从20例健康患者的图像中计算出轮廓曲线，并用于识别左前降支（LAD）、右冠状动脉和左旋支（LCx）冠状动脉中显著的冠状动脉疾病（直径狭窄大于或等于70%）。在一组86例患者中，心尖或中间平面的异常能最佳地识别节段性冠状动脉疾病。当在110例患者的测试组中对这些异常进行前瞻性评估时，LAD冠状动脉疾病的敏感性和特异性分别为79%和93%，右冠状动脉疾病为90%和90%，LCx冠状动脉疾病为83%和83%。与平面和断层图像的定性解读相比，定量断层摄影显著提高了铊201显像在检测有或无既往心肌梗死患者的LAD、右冠状动脉和LCx冠状动脉疾病方面的敏感性（P小于0.001）。
