Lancaster J L, Starling M R, Kopp D T, Lasher J C, Blumhardt R
J Nucl Med. 1985 Dec;26(12):1445-55.
Cardiac phantom studies were performed with and without a defect present to test the hypothesis that myocardial 201TI quantitative circumferential washout profile curves calculated from planar and rotating slant hole (RSH) collimator tomographic images are equally affected by errors in axial repositioning. Simulated stress images were acquired with the long axis of the phantom perpendicular to the camera surface and redistribution images were acquired to represent 50% 201TI washout with axial repositioning errors relative to the stress position ranging from 0 to 20 degrees in 5 degrees increments. There was a decrease in the 201TI washout profile curves compared to that expected (50%) in the wall tilted away from the camera surface, and a reciprocal increase in the 201TI washout profile curves in the wall tilted towards the camera surface for both imaging techniques whether a lesion was present or not. This effect became more pronounced as the error in axial repositioning was increased for both the planar (p less than 0.001) and the RSH tomographic (p less than 0.001) techniques. However, the deviation of the 201TI washout profile curves from that expected (50%) was greater for the planar imaging technique with or without a lesion (p less than 0.05 to 0.001). Thus, we conclude that 201TI quantitative circumferential washout profile curves calculated using this tomographic imaging technique are less affected by errors in axial repositioning than those calculated using an equivalent projection by standard planar imaging methods. These data emphasize the importance which must be placed on the repositioning of patients to obtain valid 201TI washout profile curves for the detection and localization of coronary artery disease.
进行了有或无缺损的心脏模型研究，以检验以下假设：从平面和旋转斜孔（RSH）准直器断层图像计算得到的心肌201铊定量圆周洗脱轮廓曲线同样会受到轴向重新定位误差的影响。模拟应激图像是在模型长轴垂直于相机表面的情况下采集的，而重新分布图像是在轴向重新定位误差相对于应激位置从0度到20度、以5度增量变化的情况下采集的，以代表50%的201铊洗脱。与预期（50%）相比，远离相机表面倾斜壁上的201铊洗脱轮廓曲线有所下降，而对于两种成像技术，无论是否存在病变，朝向相机表面倾斜壁上的201铊洗脱轮廓曲线则相应增加。随着轴向重新定位误差的增加，这种效应在平面（p<0.001）和RSH断层（p<0.001）技术中都变得更加明显。然而，无论有无病变，平面成像技术的201铊洗脱轮廓曲线与预期（50%）的偏差都更大（p<0.05至0.001）。因此，我们得出结论，使用这种断层成像技术计算得到的201铊定量圆周洗脱轮廓曲线比使用标准平面成像方法的等效投影计算得到的曲线受轴向重新定位误差的影响更小。这些数据强调了为获得用于检测和定位冠状动脉疾病的有效201铊洗脱轮廓曲线而对患者进行重新定位的重要性。
