术前吸入布地奈德联合静脉用地塞米松对甲状腺切除术患者术后咽喉痛的影响：一项随机对照试验。

Effects of preoperative inhaled budesonide combined with intravenous dexamethasone on postoperative sore throat in patients who underwent thyroidectomy: A randomized controlled trial.

机构信息

Department of Gastrointestinal Surgery, The Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang, China.

Department of Thyroid and Breast Surgery, The Affiliated People's Hospital of Ningbo University, Ningbo, Zhejiang, China.

出版信息

Medicine (Baltimore). 2024 May 17;103(20):e38235. doi: 10.1097/MD.0000000000038235.

DOI:10.1097/MD.0000000000038235

PMID:38758857

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11098170/

Abstract

BACKGROUND

This randomized controlled trial aimed to evaluate the efficacy of preoperative inhaled budesonide combined with intravenous dexamethasone on postoperative sore throat (POST) after general anesthesia in patients who underwent thyroidectomy.

METHODS

Patients who underwent elective thyroidectomy were randomly divided into the intravenous dexamethasone group (group A) and budesonide inhalation combined with intravenous dexamethasone group (group B). All patients underwent general anesthesia. The incidence and severity of POST, hoarseness, and cough at 1, 6, 12, and 24 hours after surgery were evaluated and compared between the 2 groups.

RESULTS

There were 48 and 49 patients in groups A and B, respectively. The incidence of POST was significantly lower at 6, 12, and 24 hours in group B than that in group A (P < .05). In addition, group B had a significantly lower incidence of coughing at 24 hours (P = .047). Compared with group A, the severity of POST was significantly lower at 6 (P = .027), 12 (P = .004), and 24 (P = .005) hours at rest, and at 6 (P = .002), 12 (P = .038), and 24 (P = .015) hours during swallowing in group B. The incidence and severity of hoarseness were comparable at each time-point between the 2 groups (P > .05).

CONCLUSION

Preoperative inhaled budesonide combined with intravenous dexamethasone reduced the incidence and severity of POST at 6, 12, and 24 hours after extubation compared with intravenous dexamethasone alone in patients who underwent thyroidectomy. Additionally, this combination decreased the incidence of postoperative coughing at 24 hours.

摘要

背景

本随机对照试验旨在评估术前吸入布地奈德联合静脉用地塞米松对甲状腺切除术全麻患者术后咽喉痛（POST）的疗效。

方法

择期行甲状腺切除术的患者随机分为静脉用地塞米松组（A 组）和布地奈德吸入联合静脉用地塞米松组（B 组）。所有患者均接受全身麻醉。评估并比较两组患者术后 1、6、12 和 24 小时时 POST、声音嘶哑和咳嗽的发生率和严重程度。

结果

A 组和 B 组分别有 48 例和 49 例患者。B 组术后 6、12 和 24 小时 POST 的发生率明显低于 A 组（P ＜0.05）。此外，B 组在术后 24 小时咳嗽的发生率明显较低（P ＝0.047）。与 A 组相比，B 组在静息时的 6（P ＝0.027）、12（P ＝0.004）和 24（P ＝0.005）小时以及吞咽时的 6（P ＝0.002）、12（P ＝0.038）和 24（P ＝0.015）小时 POST 的严重程度明显较低。两组在各时间点的声音嘶哑发生率和严重程度均无差异（P ＞0.05）。