Department of Anaesthesia and Intensive Care, Government Medical College and Hospital, Sector 32, Chandigarh, 160030, India.
Department of Anaesthesia and Intensive Care, Dr. B.R. Ambedkar State Institute of Medical Sciences, Sector 57, Sahibzada Ajit Singh Nagar, Punjab, 160055, India.
BMC Anesthesiol. 2024 May 1;24(1):164. doi: 10.1186/s12871-024-02534-5.
Post-operative sore throat (POST) has an incidence ranging from 21 to 80%. To prevent the development of POST, several pharmacological measures have been tried. Aim of this study was to compare the efficacy of preoperative zinc, magnesium and budesonide gargles in reducing the incidence and severity of POST in patients who underwent endotracheal intubation for elective surgeries.
We conducted a prospective, randomized, double-blind, controlled equivalence trial in 180 patients admitted for elective surgical procedures under general anaesthesia. Patients were randomised into three groups; group Z received 40 mg Zinc, group M received 250 mg Magnesium Sulphate and group B received 200 µg Budesonide in the form of 30 ml tasteless and colourless gargle solutions. Sore throat assessment and haemodynamic recording was done postoperatively at immediate recovery (0 h) and 2, 4, 6, 8, 12 and 24 h post-operatively. POST was graded on a four-point scale (0-3).
POST score was comparable at all recorded time points i.e. 0,2,4,6,8,12 and 24 h. Maximum incidence was seen at 8 h in group B (33.3%) and the minimum incidence was at 24 h in group Z (10%) (p > 0.05). It was found that the incidence of POST was more in the surgeries lasting longer than 2 h in all groups. This difference was found to be statistically significant in Groups M and B. The incidence of POST was found to be comparable between laparoscopic and open procedures.
Magnesium, zinc and budesonide have an equivocal effect in the prevention of POST at different time points. The incidence of sore throat increases significantly in surgeries lasting more than two hours if magnesium or budesonide have been used as premedicant. Duration of surgery is an independent predictor for POST.
CTRI/2021/05/033741 Date-24/05/2021(Clinical Trial Registry of India).
术后咽喉痛（POST）的发生率为 21%至 80%。为了预防 POST 的发生，已经尝试了几种药物治疗措施。本研究的目的是比较术前使用锌、镁和布地奈德漱口液减少择期手术患者气管插管后 POST 发生率和严重程度的效果。
我们在 180 名接受全身麻醉下择期手术的患者中进行了一项前瞻性、随机、双盲、对照等效试验。患者随机分为三组；Z 组接受 40mg 锌，M 组接受 250mg 硫酸镁，B 组接受 200μg 布地奈德，形式为 30ml 无味无色漱口液。术后即刻恢复（0 小时）和术后 2、4、6、8、12 和 24 小时进行咽喉痛评估和血流动力学记录。POST 按四级评分（0-3 分）进行评分。
所有记录时间点（即 0、2、4、6、8、12 和 24 小时）的 POST 评分无差异。B 组 8 小时时发生率最高（33.3%），Z 组 24 小时时发生率最低（10%）（p>0.05）。发现在所有组中，手术持续时间超过 2 小时的情况下 POST 发生率更高。在 M 组和 B 组中，这种差异具有统计学意义。腹腔镜和开放手术的 POST 发生率无差异。
镁、锌和布地奈德在不同时间点预防 POST 的效果相当。如果术前使用镁或布地奈德，手术时间超过 2 小时时，咽喉痛的发生率会显著增加。手术时间是 POST 的独立预测因素。
CTRI/2021/05/033741 日期-2021 年 5 月 24 日（印度临床试验注册处）。
