利用鱿鱼笔的特性制备低聚盐酸壳聚糖。
Exploiting specific properties of squid pens for the preparation of oligochitosan hydrochloride.
机构信息
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991, Moscow, Russia.
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991, Moscow, Russia.
出版信息
Carbohydr Res. 2024 Jun;540:109140. doi: 10.1016/j.carres.2024.109140. Epub 2024 May 3.
Herein, we describe in first the application of squid pens for the preparation of pharmaceutical-grade oligochitosan hydrochloride with the physicochemical characteristics corresponding with the requirements of the European Pharmacopoeia. It is shown that the use of specific properties of squid pens as a source of parent chitosan allows preparing the product with a high yield at relatively moderate process conditions used for squid pens treatments and chitosan depolymerization.
本文首次描述了利用鱿鱼笔制备符合欧洲药典要求的药用级低聚盐酸壳聚糖的方法。研究表明，利用鱿鱼笔作为壳聚糖原料的特性，可以在相对温和的处理条件和壳聚糖解聚条件下，以较高的产率制备该产品。
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