McAlister W H, Siegel M J, Shackelford G D, Perlman J M, Ternberg J L, Bower R J
AJR Am J Roentgenol. 1985 Oct;145(4):687-91. doi: 10.2214/ajr.145.4.687.
The clinical and radiographic findings of eight low-birth-weight neonates (mean, 900 g) with perforations of the duodenum or jejunum associated with transpyloric feedings are reported. In four patients, the perforations occurred distal to any known tube position. In experimental studies in young rabbits, Silastic or polyvinyl chloride tubes were sewn in place with the tube tips in the proximal duodenum or proximal jejunum, and either normal oral feedings or feedings through the tubes were given. Perforations and gross or microscopic abnormalities of the bowel mucosa in the area of the tubes and beyond were more frequent in rabbits with tube feedings than those given normal oral feedings. It appears that tube feedings induce some degree of mucosal damage and contribute to bowel perforation.
报告了8例低体重新生儿（平均900克）十二指肠或空肠穿孔与经幽门喂养相关的临床和影像学表现。4例患者的穿孔发生在任何已知导管位置的远端。在幼兔的实验研究中，将硅橡胶或聚氯乙烯导管缝于十二指肠近端或空肠近端，分别给予正常经口喂养或经导管喂养。与正常经口喂养的兔子相比，经导管喂养的兔子在导管所在区域及以外的肠黏膜穿孔和大体或显微镜下异常更为常见。似乎经导管喂养会导致一定程度的黏膜损伤并促使肠穿孔。
