Rodríguez A, Fernández M, Sanz M L, Oehling A
Allergol Immunopathol (Madr). 1985 May-Jun;13(3):241-8.
In view of the lack of agreement among the various authors regarding the pathogenesis of atopic dermatitis (AD) we decided to conduct an immunological study on patients affected by atopic dermatitis, whether associated with allergic respiratory disease or not. Twenty five patients were studied using T lymphocytes and their subpopulations, the lymphoblastic transformation test and serum immunoglobulin parameters. We found a decrease in the T mu/T gamma ratio in patients with pure AD relative to those with associated respiratory disease as well as a direct correlation between the T mu/T gamma ratio and IgE, which support the role of the T regulatory system in IgE production.
鉴于不同作者对于特应性皮炎（AD）发病机制的观点缺乏一致性，我们决定对患有特应性皮炎的患者进行一项免疫学研究，无论其是否伴有过敏性呼吸道疾病。我们使用T淋巴细胞及其亚群、淋巴细胞转化试验和血清免疫球蛋白参数对25名患者进行了研究。我们发现，单纯患有AD的患者相对于伴有呼吸道疾病的患者，其Tμ/Tγ比值降低，并且Tμ/Tγ比值与IgE之间存在直接相关性，这支持了T调节系统在IgE产生中的作用。
