斑马鱼中枢神经系统中的神经胶质可塑性。

Glial plasticity in the zebrafish central nervous system.

机构信息

John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK; Department of Genetics, University of Cambridge, Downing Site, Cambridge CB2 3EH, UK.

Department of Genetics, University of Cambridge, Downing Site, Cambridge CB2 3EH, UK.

出版信息

Trends Cell Biol. 2024 Jul;34(7):531-534. doi: 10.1016/j.tcb.2024.04.006. Epub 2024 May 16.

DOI:10.1016/j.tcb.2024.04.006

PMID:38760196

Abstract

Glial cells have a remarkable plasticity. Recent studies using zebrafish as a model highlight conserved cellular behavior in health and disease in the central nervous system (CNS) between zebrafish and humans. These findings inform our understanding of their function and how their dysregulation in pathogenesis can be determinant.

摘要

胶质细胞具有显著的可塑性。最近使用斑马鱼作为模型的研究强调了中枢神经系统（CNS）中斑马鱼和人类之间在健康和疾病状态下的保守细胞行为。这些发现为我们理解它们的功能以及它们在发病机制中的失调如何成为决定因素提供了信息。