Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA. Electronic address: https://twitter.com/asaf_maoz.
Harvard Medical School, Boston, MA, USA; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 75 Francis Street, Boston MA 02115, USA; Division of Cancer Genetics and Prevention, 450 Brookline Avenue, Boston MA 02215, USA. Electronic address: https://twitter.com/Dr_NJRodriguez.
Hematol Oncol Clin North Am. 2024 Aug;38(4):783-811. doi: 10.1016/j.hoc.2024.04.002. Epub 2024 May 17.
Gastrointestinal cancers are a leading cause of cancer morbidity and mortality. Many gastrointestinal cancers develop from cancer precursor lesions, which are commonly found in individuals with hereditary cancer syndromes. Hereditary cancer syndromes have advanced our understanding of cancer development and progression and have facilitated the evaluation of cancer prevention and interception efforts. Common gastrointestinal hereditary cancer syndromes, including their organ-specific cancer risk and surveillance recommendations, are reviewed in this article. The management of common gastroesophageal, pancreatic, and colonic precursor lesions is also discussed, regardless of their genetic background. Further research is needed to advance chemoprevention and immunoprevention strategies.
胃肠道癌症是癌症发病率和死亡率的主要原因。许多胃肠道癌症源自癌前病变，这些病变在遗传性癌症综合征患者中很常见。遗传性癌症综合征使我们对癌症的发生和发展有了更深入的了解，并有助于评估癌症的预防和干预措施。本文回顾了常见的胃肠道遗传性癌症综合征，包括其特定于器官的癌症风险和监测建议。本文还讨论了常见的胃食管、胰腺和结肠前体病变的治疗，无论其遗传背景如何。需要进一步的研究来推进化学预防和免疫预防策略。
