Department of Nephrology, Ningbo Medical Center Lihuili Hospital, No. 1111 Jiangnan Road, Yinzhou District, Ningbo, 315099, Zhejiang, China.
Urology & Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310014, Zhejiang, China.
BMC Complement Med Ther. 2024 May 17;24(1):194. doi: 10.1186/s12906-024-04485-3.
To study the effect of mindfulness meditation combined with progressive muscle relaxation training on the clinical efficacy and quality of life in patients with sarcopenia receiving maintenance haemodialysis (MHD).
Eligible patients with sarcopenia in our hospital were randomly assigned to a control group (n = 24) and an intervention group (n = 25). The control group received conventional dialysis treatment, while the intervention group underwent mindfulness meditation combined with progressive muscle relaxation training during the interdialysis period in addition to conventional dialysis treatment. The effect of the intervention was evaluated after 12 weeks.
There were no significant differences in the baseline values of various parameters between the two groups. Exercise capacity (sit-to-stand test,handgrip,time to 10 sit-ups) significantly improved in the intervention group after 12 weeks (32.68 ± 8.32 vs 26.50 ± 6.83; 37.42 ± 10.12 vs 28.12 ± 8.51; 19.8 ± 5.40 vs 25.29 ± 7.18) (p < 0.05). In terms of the kidney disease quality of life (KDQOL) score, all other dimensions except sexual function, social functioning, burden of kidney disease and work status dimensions showed significant improvement compared to the baseline (p < 0.05). In the control group, only the dialysis staff encouragement (DSE) and patient satisfaction (PS) dimensions showed slight improvements compared to the baseline (p > 0.05). When compared with the control group, the intervention group showed significant improvements in 10 dimensions of exercise capacity and KDQOL scores for physical function, role-physical, general health, energy, symptom/problem list, sleep, DSE, pain, cognitive function, emotional well-being and patient PS after 12 weeks (61.30 ± 5.38 vs 42.98 ± 5.73; 57.50 ± 3.55 vs 50.70 ± 3.62) (p < 0.05). Some inflammatory markers, such as the levels of interleukin-6 and high-sensitivity C-reactive protein (30.29 ± 2.96 vs 17.65 ± 3.22; 8.93 ± 0.99 vs 3.02 ± 0.34), showed a decrease during the intervention, while albumin and prealbumin levels were significantly increased compared with the baseline (30.62 ± 1.65 vs 35.60 ± 1.68; 0.32 ± 0.05 vs 0.44 ± 0.07) (p < 0.05).
Combined intervention training can improve the motor ability and quality of life of patients with sarcopenia within a short period of time.
研究正念冥想联合渐进性肌肉放松训练对维持性血液透析（MHD）患者肌少症的临床疗效和生活质量的影响。
选取我院肌少症患者，随机分为对照组（n=24）和干预组（n=25）。对照组接受常规透析治疗，干预组在常规透析治疗的基础上，在透析间期进行正念冥想联合渐进性肌肉放松训练。干预 12 周后评估干预效果。
两组患者各参数基线值无显著性差异。干预 12 周后，干预组运动能力（坐站试验、握力、10 次坐起时间）明显改善（32.68±8.32 比 26.50±6.83；37.42±10.12 比 28.12±8.51；19.8±5.40 比 25.29±7.18）（p<0.05）。在肾脏病生存质量（KDQOL）评分方面，除性功能、社会功能、肾脏疾病负担和工作状态维度外，其他所有维度均较基线显著改善（p<0.05）。对照组仅透析工作人员鼓励（DSE）和患者满意度（PS）维度较基线略有改善（p>0.05）。与对照组相比，干预组运动能力和 KDQOL 评分的身体功能、角色身体、一般健康、能量、症状/问题列表、睡眠、DSE、疼痛、认知功能、情绪健康和患者 PS 10 个维度在干预 12 周后均有显著改善（61.30±5.38 比 42.98±5.73；57.50±3.55 比 50.70±3.62）（p<0.05）。一些炎症标志物，如白细胞介素-6 和高敏 C 反应蛋白水平（30.29±2.96 比 17.65±3.22；8.93±0.99 比 3.02±0.34）在干预期间下降，而白蛋白和前白蛋白水平较基线显著升高（30.62±1.65 比 35.60±1.68；0.32±0.05 比 0.44±0.07）（p<0.05）。
联合干预训练可以在短时间内提高肌少症患者的运动能力和生活质量。
