Huang Xiaohong, Lv Jing, Zhu Dongxu, Peng Haining, Yu Tengbo
Shandong Institute of Traumatic Orthopedics, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Psychology, School of Social Development and Public Policy, Fudan University, Shanghai, China.
Biogerontology. 2025 Jul 18;26(4):145. doi: 10.1007/s10522-025-10287-y.
Mindfulness cultivates awareness, presence, and non-judgmental acceptance, enhancing overall well-being. Inflammaging, linking age and aged-related diseases, manifests through heightened levels of IL-6, TNF-α, and CRP, impacting aging indicators like TA, TL, PWV, and FMD. To assess how mindfulness-based interventions (MBIs) affect inflammaging, a search was conducted in PubMed, Web of Science, Cochrane Central Register, and ProQuest Dissertation & Theses Global up to March 2024. Criteria included English articles and dissertations with participants over 18. Selected studies were randomized controlled trials (RCTs) and pre-post trials evaluating biomarkers related to inflammaging. Standardized mean differences were calculated using Morris's d for RCTs and Cohen's d for uncontrolled pre-post trials. Eighty-nine studies were included. In RCTs, MBIs reduced levels of TNF-α (d = -0.40), IL-6 (d = -0.70), CRP (d = -0.48), and PWV (d = -0.30) while increasing FMD (d = 0.24), TL (d = 0.43) and TA (d = 0.84). Pre-post trials indicated MBIs reduced TNF-α (d = -0.17), IL-6 (d = -0.33) and CRP (d = -0.33). Moderator analyses highlighted that MBIs other than mainstream mindfulness practices were found to be more effective in reducing IL-6 and CRP, and MBIs were particularly effective in reducing TNF-α among those with diseases. The main analysis revealed moderate certainty evidence from RCTs and uncontrolled pre-post trials supporting a causal relationship between mindfulness practices and inflammaging-related responses. The findings suggest that exploring alternative types of MBIs beyond mainstream approaches may yield more sustained benefits in attenuating inflammaging.
正念培养意识、专注和无评判的接纳，提升整体幸福感。炎症衰老将年龄与年龄相关疾病联系起来，通过白细胞介素-6、肿瘤坏死因子-α和C反应蛋白水平升高表现出来，影响诸如踝臂指数、端粒长度、脉搏波速度和血流介导的血管舒张等衰老指标。为了评估基于正念的干预措施（MBIs）如何影响炎症衰老，截至2024年3月，在PubMed、科学网、Cochrane中心注册库和ProQuest全球博硕士论文数据库中进行了检索。纳入标准包括参与者年龄超过18岁的英文文章和论文。选定的研究为随机对照试验（RCTs）和前后对照试验，评估与炎症衰老相关的生物标志物。使用莫里斯d值计算随机对照试验的标准化均数差，使用科恩d值计算非对照前后对照试验的标准化均数差。共纳入89项研究。在随机对照试验中，基于正念的干预措施降低了肿瘤坏死因子-α（d = -0.40）、白细胞介素-6（d = -0.70）、C反应蛋白（d = -0.48）和脉搏波速度（d = -0.30）水平，同时增加了血流介导的血管舒张（d = 0.24）、端粒长度（d = 0.43）和踝臂指数（d = 0.84）。前后对照试验表明，基于正念的干预措施降低了肿瘤坏死因子-α（d = -0.17）、白细胞介素-6（d = -0.33）和C反应蛋白（d = -0.33）。调节因素分析强调，发现主流正念练习以外的基于正念的干预措施在降低白细胞介素-6和C反应蛋白方面更有效，且基于正念的干预措施在患有疾病的人群中降低肿瘤坏死因子-α方面特别有效。主要分析揭示，来自随机对照试验和非对照前后对照试验的中等确定性证据支持正念练习与炎症衰老相关反应之间的因果关系。研究结果表明，探索主流方法以外的其他类型的基于正念的干预措施可能在减轻炎症衰老方面产生更持久的益处。
