Drobinski G, Eugène M, Vachon J M, Béjean-Lebuisson A, Evans J I, Kin G, Grosgogeat Y
Arch Mal Coeur Vaiss. 1979 Apr;72(4):332-40.
Characteristic echocardiographic features of hypertrophic obstructive cardiomyopathy were recorded in 24 patients, all of whom had asymmetric septal hypertrophy and systolic anterior motion of the mitral valve (SAM) at rest or after pharmacodynamic stimulation. The relationship between outflow tract obstruction and SAM was assessed by comparison with data obtained at cardiac catheterisation and external mechanography: SAM seems to be a non-specific phenomenon and may be recorded in cases of hypertrophic cardiomyopathy without obstruction during pharmacodynamic stimulation. In forms with obstruction, SAM and the severity of obstruction increase with the degree of spetal hypertrophy. The increased contractility of the left ventricular posterior wall appears to be an important factor in the mechanism of SAM which can be prevented by betablockade in moderate or labile forms. When SAM is permanent, whatever the gradient recorded, it is a sign of anatomical deformation of the left ventricle and may be an additional indication for cardiac surgery.
24例患者记录到肥厚型梗阻性心肌病的特征性超声心动图表现,所有患者均有不对称性室间隔肥厚以及静息时或药效学刺激后二尖瓣收缩期前向运动(SAM)。通过与心导管检查及体外力学描记法所获数据进行比较,评估流出道梗阻与SAM之间的关系:SAM似乎是一种非特异性现象,在药效学刺激期间,肥厚型心肌病无梗阻的病例中也可能记录到。在有梗阻的类型中,SAM及梗阻严重程度随室间隔肥厚程度增加而加重。左心室后壁收缩性增强似乎是SAM机制中的一个重要因素,在中度或不稳定型中,β受体阻滞剂可预防SAM。当SAM持续存在时,无论记录到的压力阶差如何,它都是左心室解剖结构变形的标志,可能是心脏手术的又一指征。