Kar Neelakshi, Logue Jeremy S
Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY, USA.
Cytoskeleton (Hoboken). 2025 Mar;82(3):91-97. doi: 10.1002/cm.21880. Epub 2024 May 18.
The tissue invasive capacity of cancer cells is determined by their phenotypic plasticity. For instance, mesenchymal to amoeboid transition has been found to facilitate the passage of cancer cells through confined environments. This phenotypic transition is also heavily regulated by the architecture of the actin cytoskeleton, which may increase myosin contractility and the intracellular pressure that is known to drive bleb formation. In this review, we highlight several Diaphanous related formins (DRFs) that have been found to promote or suppress bleb formation in cancer cells, which is a hallmark of amoeboid migration. Based on the work discussed here, the role of the DRFs in cancer(s) is worthy of further scrutiny in animal models, as they may prove to be therapeutic targets.
癌细胞的组织侵袭能力取决于其表型可塑性。例如，已发现间充质向阿米巴样转变有助于癌细胞在受限环境中通过。这种表型转变也受到肌动蛋白细胞骨架结构的严格调控，肌动蛋白细胞骨架结构可能会增加肌球蛋白收缩力和已知驱动气泡形成的细胞内压力。在本综述中，我们重点介绍了几种已被发现促进或抑制癌细胞气泡形成的Diaphanous相关formin（DRF）蛋白，气泡形成是阿米巴样迁移的一个标志。基于此处讨论的工作，DRF蛋白在癌症中的作用值得在动物模型中进一步研究，因为它们可能被证明是治疗靶点。
