Popova N K, Kulikov A V, Pak D F
Biull Eksp Biol Med. 1985 Sep;100(9):322-4.
The number of serotonin type 2 receptors (S2) was measured in the frontal cortex of mice belonging to 7 inbred strains using specific 3H-spiperone binding. In the same mice, measurements were also taken of the number of 5-hydroxytryptophan-induced (200 mg/kg i.p.) of head twitches (HT). A significant positive interspecific correlation was demonstrated between the number of S2 and HT. The conclusion is drawn that in the frontal cortex 3H-spiperone is bound to functionally active S2 and that the intensity of HT is largely controlled by the genetically determined number of S2 in the brain.
使用特异性3H-司哌罗宁结合法，测定了属于7个近交系的小鼠额叶皮质中血清素2型受体（S2）的数量。对相同的小鼠，还测量了5-羟色氨酸（200mg/kg腹腔注射）诱导的头部抽搐（HT）的次数。结果显示，S2的数量与HT次数之间存在显著的种间正相关。由此得出结论：在额叶皮质中，3H-司哌罗宁与功能活性S2结合，并且HT的强度在很大程度上受大脑中S2的遗传决定数量的控制。
