相位角作为慢性阻塞性肺疾病患者肌肉减少症和营养不良的指标。
Phase angle as an indicator of sarcopenia and malnutrition in patients with chronic obstructive pulmonary disease.
机构信息
Department of Rehabilitation, Tohoku Medical and Pharmaceutical University Wakabayashi Hospital, 2-29-1, Yamatomachi, Wakabayashi-ku, Sendai 984-8560, Miyagi, Japan; Department of Occupational Health, Tohoku University Graduate School of Medicine, 2-1, Seiryomachi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
Department of Rehabilitation, Tohoku Medical and Pharmaceutical University Wakabayashi Hospital, 2-29-1, Yamatomachi, Wakabayashi-ku, Sendai 984-8560, Miyagi, Japan.
出版信息
Respir Investig. 2024 Jul;62(4):651-656. doi: 10.1016/j.resinv.2024.05.012. Epub 2024 May 17.
BACKGROUND
Phase angle (PhA), which is measured using bioelectrical impedance analysis, is an indicator of muscle quality and malnutrition. PhA has been shown to be correlated with sarcopenia and malnutrition; however, studies on patients with chronic obstructive pulmonary disease (COPD) are limited. In this study, we investigated the correlation between PhA and sarcopenia and malnutrition and determined the cutoff values of PhA for those in patients with COPD.
METHODS
This study included 105 male patients with COPD (mean age 75.7 ± 7.7 years, mean forced expiratory volume in 1s % predicted [%FEV] 57.0 ± 20.1%) and 12 male controls (mean age 74.1 ± 3.8 years) who were outpatients between December 2019 and March 2024. PhA was measured using the InBody S10, and its correlation with sarcopenia and malnutrition was assessed. The cutoff PhA values for sarcopenia and malnutrition were determined using receiver operating characteristic curves.
RESULTS
The prevalence rates of sarcopenia and malnutrition were 31% and 22%, respectively, in patients with COPD. PhA significantly correlated with sarcopenia- and malnutrition-related indicators. Multivariate logistic regression analysis independently correlated PhA with sarcopenia and malnutrition. The cutoff values of the PhA for sarcopenia and malnutrition were 4.75° (AUC = 0.78, 95% CI = 0.68-0.88) and 4.25° (AUC = 0.75, 95% CI = 0.63-0.86), respectively.
CONCLUSIONS
PhA was significantly correlated with sarcopenia and malnutrition in Japanese patients with COPD and may be a useful diagnostic indicator.
背景
相位角（PhA）是一种通过生物电阻抗分析测量的指标，它是肌肉质量和营养不良的指标。已经证明 PhA 与肌肉减少症和营养不良有关；然而，关于慢性阻塞性肺疾病（COPD）患者的研究有限。在这项研究中，我们研究了 PhA 与肌肉减少症和营养不良的相关性，并确定了 COPD 患者 PhA 的截断值。
方法
这项研究包括 105 名男性 COPD 患者（平均年龄 75.7±7.7 岁，第 1 秒用力呼气量预计值的百分比 [%FEV] 57.0±20.1%）和 12 名男性对照组（平均年龄 74.1±3.8 岁），他们是 2019 年 12 月至 2024 年 3 月之间的门诊患者。使用 InBody S10 测量 PhA，并评估其与肌肉减少症和营养不良的相关性。使用受试者工作特征曲线确定肌肉减少症和营养不良的 PhA 截断值。
结果
COPD 患者的肌肉减少症和营养不良患病率分别为 31%和 22%。PhA 与肌肉减少症和营养不良相关指标显著相关。多变量逻辑回归分析独立地将 PhA 与肌肉减少症和营养不良相关联。肌肉减少症和营养不良的 PhA 截断值分别为 4.75°（AUC=0.78，95%CI=0.68-0.88）和 4.25°（AUC=0.75，95%CI=0.63-0.86）。
结论
PhA 与日本 COPD 患者的肌肉减少症和营养不良显著相关，可能是一种有用的诊断指标。
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