School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411 Punjab, India.
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411 Punjab, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Drug Discov Today. 2024 Jul;29(7):104030. doi: 10.1016/j.drudis.2024.104030. Epub 2024 May 17.
In recent years, microneedles (MNs) have been transformed to serve a wide range of applications in the biomedical field. Their role as sensors in wearable devices has provided an alternative to blood-based monitoring of health and diagnostic methods. Hence, they have become a topic of research interest for several scientists working in the biomedical field. These MNs as sensors offer the continuous monitoring of biomarkers like glucose, nucleic acids, proteins, polysaccharides and electrolyte ions, which can therefore screen for and diagnose disease conditions in humans. The present review focuses on types of MN sensors and their applications. Various clinical trials and bottlenecks of MN R&D are also discussed.
近年来，微针 (MNs) 已经转变为在生物医学领域中应用广泛。它们作为可穿戴设备中的传感器，为基于血液的健康监测和诊断方法提供了替代方案。因此，它们成为了生物医学领域的几位科学家研究的课题。这些作为传感器的 MNs 可以提供对生物标志物（如葡萄糖、核酸、蛋白质、多糖和电解质离子）的连续监测，从而可以筛查和诊断人类的疾病状况。本综述重点介绍了 MN 传感器的类型及其应用。还讨论了各种临床试验和 MN 研发的瓶颈。
