Kaur Simran Deep, Choudhary Shivanshu, Sen Santimoy, Pemmaraju Deepak B, Singh Sachin Kumar, Kapoor Deepak N
School of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, 173229, India.
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, Assam, 781101, India.
Drug Deliv Transl Res. 2025 Jan 29. doi: 10.1007/s13346-025-01802-2.
Myocardial infarction is a condition where the heart muscle is damaged due to clogged coronary arteries. There are limited treatment options for treating myocardial infarction. Microneedle patches have recently become popular as a possibly viable therapy for myocardial. By adhering to the surface of the heart, these microneedle patches provide mechanical support, regenerative medicines, or cells directly to the injured tissue allowing for targeted treatment. These microneedle patches resolve the drawbacks of systemic therapy by facilitating targeted administration and integration with the goal of restoring damaged heart function. Recent advances in fabrication methods and current perspectives on the therapeutic advantages of cardiac microneedles patches used in the treatment of myocardial infarction are summarized in this review. Although the data is less in this area this review provides an avenue for the formulation scientist working in biomedical science to develop such microneedle patches for clinical applications in cardiology.
心肌梗死是一种由于冠状动脉堵塞导致心肌受损的病症。治疗心肌梗死的选择有限。微针贴片最近作为一种可能可行的心肌治疗方法而受到欢迎。通过粘附在心脏表面，这些微针贴片可直接为受损组织提供机械支持、再生药物或细胞，从而实现靶向治疗。这些微针贴片通过促进靶向给药和整合，以恢复受损心脏功能为目标，解决了全身治疗的缺点。本文综述了制造方法的最新进展以及用于治疗心肌梗死的心脏微针贴片的治疗优势的当前观点。尽管该领域的数据较少，但本综述为从事生物医学科学的制剂科学家开发此类用于心脏病学临床应用的微针贴片提供了一条途径。
